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Global hypomethylation in childhood asthma identified by genome-wide DNA-methylation sequencing preferentially affects enhancer regions.
Thürmann L, Klös M, Mackowiak SD, Bieg M, Bauer T, Ishaque N, Messingschlager M, Herrmann C, Röder S, Bauer M, Schäuble S, Faessler E, Hahn U, Weichenhan D, Mücke O, Plass C, Borte M, von Mutius E, Stangl GI, Lauener R, Karvonen AM, Divaret-Chauveau A, Riedler J, Heinrich J, Standl M, von Berg A, Schaaf B, Herberth G, Kabesch M, Eils R, Trump S, Lehmann I. Thürmann L, et al. Among authors: messingschlager m. Allergy. 2023 Jun;78(6):1489-1506. doi: 10.1111/all.15658. Epub 2023 Feb 10. Allergy. 2023. PMID: 36704932
Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19.
Trump S, Lukassen S, Anker MS, Chua RL, Liebig J, Thürmann L, Corman VM, Binder M, Loske J, Klasa C, Krieger T, Hennig BP, Messingschlager M, Pott F, Kazmierski J, Twardziok S, Albrecht JP, Eils J, Hadzibegovic S, Lena A, Heidecker B, Bürgel T, Steinfeldt J, Goffinet C, Kurth F, Witzenrath M, Völker MT, Müller SD, Liebert UG, Ishaque N, Kaderali L, Sander LE, Drosten C, Laudi S, Eils R, Conrad C, Landmesser U, Lehmann I. Trump S, et al. Among authors: messingschlager m. Nat Biotechnol. 2021 Jun;39(6):705-716. doi: 10.1038/s41587-020-00796-1. Epub 2020 Dec 24. Nat Biotechnol. 2021. PMID: 33361824
Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children.
Loske J, Röhmel J, Lukassen S, Stricker S, Magalhães VG, Liebig J, Chua RL, Thürmann L, Messingschlager M, Seegebarth A, Timmermann B, Klages S, Ralser M, Sawitzki B, Sander LE, Corman VM, Conrad C, Laudi S, Binder M, Trump S, Eils R, Mall MA, Lehmann I. Loske J, et al. Among authors: messingschlager m. Nat Biotechnol. 2022 Mar;40(3):319-324. doi: 10.1038/s41587-021-01037-9. Epub 2021 Aug 18. Nat Biotechnol. 2022. PMID: 34408314
Genome-wide DNA methylation sequencing identifies epigenetic perturbations in the upper airways under long-term exposure to moderate levels of ambient air pollution.
Messingschlager M, Bartel-Steinbach M, Mackowiak SD, Denkena J, Bieg M, Klös M, Seegebarth A, Straff W, Süring K, Ishaque N, Eils R, Lehmann I, Lermen D, Trump S. Messingschlager M, et al. Environ Res. 2023 Sep 15;233:116413. doi: 10.1016/j.envres.2023.116413. Epub 2023 Jun 20. Environ Res. 2023. PMID: 37343754 Free article.
Pharmacological Improvement of CFTR Function Rescues Airway Epithelial Homeostasis and Host Defense in Children with Cystic Fibrosis.
Loske J, Völler M, Lukassen S, Stahl M, Thürmann L, Seegebarth A, Röhmel J, Wisniewski S, Messingschlager M, Lorenz S, Klages S, Eils R, Lehmann I, Mall MA, Graeber SY, Trump S. Loske J, et al. Among authors: messingschlager m. Am J Respir Crit Care Med. 2024 Jan 23. doi: 10.1164/rccm.202310-1836OC. Online ahead of print. Am J Respir Crit Care Med. 2024. PMID: 38259174