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NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease.
Ryan EM, Sadiku P, Coelho P, Watts ER, Zhang A, Howden AJM, Sanchez-Garcia MA, Bewley M, Cole J, McHugh BJ, Vermaelen W, Ghesquiere B, Carmeliet P, Rodriguez Blanco G, Von Kriegsheim A, Sanchez Y, Rumsey W, Callahan JF, Cooper G, Parkinson N, Baillie K, Cantrell DA, McCafferty J, Choudhury G, Singh D, Dockrell DH, Whyte MKB, Walmsley SR. Ryan EM, et al. Among authors: carmeliet p. Am J Respir Crit Care Med. 2023 Apr 15;207(8):998-1011. doi: 10.1164/rccm.202203-0482OC. Am J Respir Crit Care Med. 2023. PMID: 36724365 Free PMC article.
HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury.
Vohwinkel CU, Burns N, Coit E, Yuan X, Vladar EK, Sul C, Schmidt EP, Carmeliet P, Stenmark K, Nozik ES, Tuder RM, Eltzschig HK. Vohwinkel CU, et al. Among authors: carmeliet p. JCI Insight. 2022 Dec 22;7(24):e157855. doi: 10.1172/jci.insight.157855. JCI Insight. 2022. PMID: 36326834 Free PMC article.
CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation.
Fernández-García J, Franco F, Parik S, Altea-Manzano P, Pane AA, Broekaert D, van Elsen J, Di Conza G, Vermeire I, Schalley T, Planque M, van Brussel T, Schepers R, Modave E, Karakach TK, Carmeliet P, Lambrechts D, Ho PC, Fendt SM. Fernández-García J, et al. Among authors: carmeliet p. Cell Rep. 2022 Nov 15;41(7):111639. doi: 10.1016/j.celrep.2022.111639. Cell Rep. 2022. PMID: 36384124 Free article.
Weak neuronal glycolysis sustains cognition and organismal fitness.
Jimenez-Blasco D, Agulla J, Lapresa R, Garcia-Macia M, Bobo-Jimenez V, Garcia-Rodriguez D, Manjarres-Raza I, Fernandez E, Jeanson Y, Khoury S, Portais JC, Padro D, Ramos-Cabrer P, Carmeliet P, Almeida A, Bolaños JP. Jimenez-Blasco D, et al. Among authors: carmeliet p. Nat Metab. 2024 May 24. doi: 10.1038/s42255-024-01049-0. Online ahead of print. Nat Metab. 2024. PMID: 38789798
The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells.
de Zeeuw P, Treps L, García-Caballero M, Harjes U, Kalucka J, De Legher C, Brepoels K, Peeters K, Vinckier S, Souffreau J, Bouché A, Taverna F, Dehairs J, Talebi A, Ghesquière B, Swinnen J, Schoonjans L, Eelen G, Dewerchin M, Carmeliet P. de Zeeuw P, et al. Among authors: carmeliet p. Commun Biol. 2024 May 23;7(1):618. doi: 10.1038/s42003-024-06186-6. Commun Biol. 2024. PMID: 38783087 Free PMC article.
FOXF1 promotes tumor vessel normalization and prevents lung cancer progression through FZD4.
Bian F, Goda C, Wang G, Lan YW, Deng Z, Gao W, Acharya A, Reza AA, Gomez-Arroyo J, Merjaneh N, Ren X, Goveia J, Carmeliet P, Kalinichenko VV, Kalin TV. Bian F, et al. Among authors: carmeliet p. EMBO Mol Med. 2024 May;16(5):1063-1090. doi: 10.1038/s44321-024-00064-8. Epub 2024 Apr 8. EMBO Mol Med. 2024. PMID: 38589650 Free PMC article.
773 results