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Reducing affinity as a strategy to boost immunomodulatory antibody agonism.
Yu X, Orr CM, Chan HTC, James S, Penfold CA, Kim J, Inzhelevskaya T, Mockridge CI, Cox KL, Essex JW, Tews I, Glennie MJ, Cragg MS. Yu X, et al. Among authors: orr cm. Nature. 2023 Feb;614(7948):539-547. doi: 10.1038/s41586-022-05673-2. Epub 2023 Feb 1. Nature. 2023. PMID: 36725933
Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.
Yu X, Chan HTC, Orr CM, Dadas O, Booth SG, Dahal LN, Penfold CA, O'Brien L, Mockridge CI, French RR, Duriez P, Douglas LR, Pearson AR, Cragg MS, Tews I, Glennie MJ, White AL. Yu X, et al. Among authors: orr cm. Cancer Cell. 2018 Apr 9;33(4):664-675.e4. doi: 10.1016/j.ccell.2018.02.009. Epub 2018 Mar 22. Cancer Cell. 2018. PMID: 29576376 Free PMC article.
Structure of the Recombinant Neisseria gonorrhoeae Adhesin Complex Protein (rNg-ACP) and Generation of Murine Antibodies with Bactericidal Activity against Gonococci.
Almonacid-Mendoza HL, Humbert MV, Dijokaite A, Cleary DW, Soo Y, Hung MC, Orr CM, Machelett MM, Tews I, Christodoulides M. Almonacid-Mendoza HL, et al. Among authors: orr cm. mSphere. 2018 Oct 10;3(5):e00331-18. doi: 10.1128/mSphere.00331-18. mSphere. 2018. PMID: 30305317 Free PMC article.
Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
El Omari K, Duman R, Mykhaylyk V, Orr CM, Latimer-Smith M, Winter G, Grama V, Qu F, Bountra K, Kwong HS, Romano M, Reis RI, Vogeley L, Vecchia L, Owen CD, Wittmann S, Renner M, Senda M, Matsugaki N, Kawano Y, Bowden TA, Moraes I, Grimes JM, Mancini EJ, Walsh MA, Guzzo CR, Owens RJ, Jones EY, Brown DG, Stuart DI, Beis K, Wagner A. El Omari K, et al. Among authors: orr cm. Commun Chem. 2023 Oct 12;6(1):219. doi: 10.1038/s42004-023-01014-0. Commun Chem. 2023. PMID: 37828292 Free PMC article.
Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1.
Fischer ES, Yu CWH, Bellini D, McLaughlin SH, Orr CM, Wagner A, Freund SMV, Barford D. Fischer ES, et al. Among authors: orr cm. EMBO Rep. 2021 Jul 5;22(7):e52242. doi: 10.15252/embr.202052242. Epub 2021 May 19. EMBO Rep. 2021. PMID: 34013668 Free PMC article.
96 results