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Late gene expression-deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV.
Hansen SG, Womack JL, Perez W, Schmidt KA, Marshall E, Iyer RF, Cleveland Rubeor H, Otero CE, Taher H, Vande Burgt NH, Barfield R, Randall KT, Morrow D, Hughes CM, Selseth AN, Gilbride RM, Ford JC, Caposio P, Tarantal AF, Chan C, Malouli D, Barry PA, Permar SR, Picker LJ, Früh K. Hansen SG, et al. Among authors: iyer rf. JCI Insight. 2023 Mar 22;8(6):e164692. doi: 10.1172/jci.insight.164692. JCI Insight. 2023. PMID: 36749635 Free PMC article.
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy.
Verweij MC, Hansen SG, Iyer R, John N, Malouli D, Morrow D, Scholz I, Womack J, Abdulhaqq S, Gilbride RM, Hughes CM, Ventura AB, Ford JC, Selseth AN, Oswald K, Shoemaker R, Berkemeier B, Bosche WJ, Hull M, Shao J, Sacha JB, Axthelm MK, Edlefsen PT, Lifson JD, Picker LJ, Früh K. Verweij MC, et al. Science. 2021 Apr 30;372(6541):eabe9233. doi: 10.1126/science.abe9233. Epub 2021 Mar 25. Science. 2021. PMID: 33766941 Free PMC article.
CD8+ T cell targeting of tumor antigens presented by HLA-E.
Iyer RF, Verweij MC, Nair SS, Morrow D, Mansouri M, Chakravarty D, Beechwood T, Meyer C, Uebelhoer L, Lauron EJ, Selseth A, John N, Thin TH, Dzedzik S, Havenar-Daughton C, Axthelm MK, Douglas J, Korman A, Bhardwaj N, Tewari AK, Hansen S, Malouli D, Picker LJ, Früh K. Iyer RF, et al. Sci Adv. 2024 May 10;10(19):eadm7515. doi: 10.1126/sciadv.adm7515. Epub 2024 May 10. Sci Adv. 2024. PMID: 38728394 Free PMC article.