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Addition of Losartan to FOLFIRINOX and Chemoradiation Reduces Immunosuppression-Associated Genes, Tregs, and FOXP3+ Cancer Cells in Locally Advanced Pancreatic Cancer.
Boucher Y, Posada JM, Subudhi S, Kumar AS, Rosario SR, Gu L, Kumra H, Mino-Kenudson M, Talele NP, Duda DG, Fukumura D, Wo JY, Clark JW, Ryan DP, Fernandez-Del Castillo C, Hong TS, Pittet MJ, Jain RK. Boucher Y, et al. Among authors: talele np. Clin Cancer Res. 2023 Apr 14;29(8):1605-1619. doi: 10.1158/1078-0432.CCR-22-1630. Clin Cancer Res. 2023. PMID: 36749873 Free PMC article. Clinical Trial.
Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
Ho WW, Gomes-Santos IL, Aoki S, Datta M, Kawaguchi K, Talele NP, Roberge S, Ren J, Liu H, Chen IX, Andersson P, Chatterjee S, Kumar AS, Amoozgar Z, Zhang Q, Huang P, Ng MR, Chauhan VP, Xu L, Duda DG, Clark JW, Pittet MJ, Fukumura D, Jain RK. Ho WW, et al. Among authors: talele np. Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2105323118. doi: 10.1073/pnas.2105323118. Proc Natl Acad Sci U S A. 2021. PMID: 34725151 Free PMC article.
Exercise Training Improves Tumor Control by Increasing CD8+ T-cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade.
Gomes-Santos IL, Amoozgar Z, Kumar AS, Ho WW, Roh K, Talele NP, Curtis H, Kawaguchi K, Jain RK, Fukumura D. Gomes-Santos IL, et al. Among authors: talele np. Cancer Immunol Res. 2021 Jul;9(7):765-778. doi: 10.1158/2326-6066.CIR-20-0499. Epub 2021 Apr 10. Cancer Immunol Res. 2021. PMID: 33839688 Free PMC article.
AKT1low Quiescent Cancer Cells Promote Solid Tumor Growth.
Alves CP, Dey-Guha I, Kabraji S, Yeh AC, Talele NP, Solé X, Chowdhury J, Mino-Kenudson M, Loda M, Sgroi D, Borresen-Dale AL, Russnes HG, Ross KN, Ramaswamy S. Alves CP, et al. Among authors: talele np. Mol Cancer Ther. 2018 Jan;17(1):254-263. doi: 10.1158/1535-7163.MCT-16-0868. Epub 2017 Oct 20. Mol Cancer Ther. 2018. PMID: 29054988 Free PMC article.