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Page 1
The evolving role of investigative toxicology in the pharmaceutical industry.
Pognan F, Beilmann M, Boonen HCM, Czich A, Dear G, Hewitt P, Mow T, Oinonen T, Roth A, Steger-Hartmann T, Valentin JP, Van Goethem F, Weaver RJ, Newham P. Pognan F, et al. Among authors: czich a. Nat Rev Drug Discov. 2023 Apr;22(4):317-335. doi: 10.1038/s41573-022-00633-x. Epub 2023 Feb 13. Nat Rev Drug Discov. 2023. PMID: 36781957 Free PMC article. Review.
Optimizing drug discovery by Investigative Toxicology: Current and future trends.
Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, Mow T, Newham P, Oinonen T, Pognan F, Roth A, Valentin JP, Van Goethem F, Weaver RJ, Birk B, Boyer S, Caloni F, Chen AE, Corvi R, Cronin MTD, Daneshian M, Ewart LC, Fitzgerald RE, Hamilton GA, Hartung T, Kangas JD, Kramer NI, Leist M, Marx U, Polak S, Rovida C, Testai E, Van der Water B, Vulto P, Steger-Hartmann T. Beilmann M, et al. Among authors: czich a. ALTEX. 2019;36(2):289-313. doi: 10.14573/altex.1808181. Epub 2018 Dec 20. ALTEX. 2019. PMID: 30570669 Free article.
Acceptable intakes (AIs) for 11 small molecule N-nitrosamines (NAs).
Bercu JP, Masuda-Herrera M, Trejo-Martin A, Sura P, Jolly R, Kenyon M, Thomas R, Ponting DJ, Snodin D, Tuschl G, Simon S, De Vlieger K, Hutchinson R, Czich A, Glowienke S, Reddy MV, Johanssen S, Vock E, Claude N, Weaver RJ. Bercu JP, et al. Among authors: czich a. Regul Toxicol Pharmacol. 2023 Aug;142:105415. doi: 10.1016/j.yrtph.2023.105415. Epub 2023 May 29. Regul Toxicol Pharmacol. 2023. PMID: 37257751 Free article.
Follow-up actions from positive results of in vitro genetic toxicity testing.
Dearfield KL, Thybaud V, Cimino MC, Custer L, Czich A, Harvey JS, Hester S, Kim JH, Kirkland D, Levy DD, Lorge E, Moore MM, Ouédraogo-Arras G, Schuler M, Suter W, Sweder K, Tarlo K, van Benthem J, van Goethem F, Witt KL. Dearfield KL, et al. Among authors: czich a. Environ Mol Mutagen. 2011 Apr;52(3):177-204. doi: 10.1002/em.20617. Epub 2010 Oct 20. Environ Mol Mutagen. 2011. PMID: 20963811 Free article. Review.
Mechanisms of Nitrosamine Mutagenicity and Their Relationship to Rodent Carcinogenic Potency.
Snodin DJ, Trejo-Martin A, Ponting DJ, Smith GF, Czich A, Cross K, Custer L, Elloway J, Greene N, Kalgutkar AS, Stalford SA, Tennant RE, Vock E, Zalewski A, Ziegler V, Dobo KL. Snodin DJ, et al. Among authors: czich a. Chem Res Toxicol. 2024 Feb 19;37(2):181-198. doi: 10.1021/acs.chemrestox.3c00327. Epub 2024 Feb 5. Chem Res Toxicol. 2024. PMID: 38316048 Review.
Letter to the editor.
Zeller A, Czich A, Guérard M, Honarvar N, Martus HJ, Pfuhler S, Vock E, Kirkland D. Zeller A, et al. Among authors: czich a. Mutat Res Genet Toxicol Environ Mutagen. 2022 Apr-May;876-877:503473. doi: 10.1016/j.mrgentox.2022.503473. Epub 2022 Feb 16. Mutat Res Genet Toxicol Environ Mutagen. 2022. PMID: 35483788 No abstract available.
Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies.
Rothfuss A, O'Donovan M, De Boeck M, Brault D, Czich A, Custer L, Hamada S, Plappert-Helbig U, Hayashi M, Howe J, Kraynak AR, van der Leede BJ, Nakajima M, Priestley C, Thybaud V, Saigo K, Sawant S, Shi J, Storer R, Struwe M, Vock E, Galloway S. Rothfuss A, et al. Among authors: czich a. Mutat Res. 2010 Sep 30;702(1):40-69. doi: 10.1016/j.mrgentox.2010.07.006. Epub 2010 Jul 23. Mutat Res. 2010. PMID: 20656055
25 results