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Page 1
The evolving role of investigative toxicology in the pharmaceutical industry.
Pognan F, Beilmann M, Boonen HCM, Czich A, Dear G, Hewitt P, Mow T, Oinonen T, Roth A, Steger-Hartmann T, Valentin JP, Van Goethem F, Weaver RJ, Newham P. Pognan F, et al. Among authors: van goethem f. Nat Rev Drug Discov. 2023 Apr;22(4):317-335. doi: 10.1038/s41573-022-00633-x. Epub 2023 Feb 13. Nat Rev Drug Discov. 2023. PMID: 36781957 Free PMC article. Review.
Optimizing drug discovery by Investigative Toxicology: Current and future trends.
Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, Mow T, Newham P, Oinonen T, Pognan F, Roth A, Valentin JP, Van Goethem F, Weaver RJ, Birk B, Boyer S, Caloni F, Chen AE, Corvi R, Cronin MTD, Daneshian M, Ewart LC, Fitzgerald RE, Hamilton GA, Hartung T, Kangas JD, Kramer NI, Leist M, Marx U, Polak S, Rovida C, Testai E, Van der Water B, Vulto P, Steger-Hartmann T. Beilmann M, et al. Among authors: van goethem f. ALTEX. 2019;36(2):289-313. doi: 10.14573/altex.1808181. Epub 2018 Dec 20. ALTEX. 2019. PMID: 30570669 Free article.
Analysis of negative historical control group data from the in vitro micronucleus assay using TK6 cells.
Lovell DP, Fellows M, Marchetti F, Christiansen J, Elhajouji A, Hashimoto K, Kasamoto S, Li Y, Masayasu O, Moore MM, Schuler M, Smith R, Stankowski LF Jr, Tanaka J, Tanir JY, Thybaud V, Van Goethem F, Whitwell J. Lovell DP, et al. Among authors: van goethem f. Mutat Res Genet Toxicol Environ Mutagen. 2018 Jan;825:40-50. doi: 10.1016/j.mrgentox.2017.10.006. Epub 2017 Nov 10. Mutat Res Genet Toxicol Environ Mutagen. 2018. PMID: 29307374 Free article.
Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy.
Verbist BM, Verheyen GR, Vervoort L, Crabbe M, Beerens D, Bosmans C, Jaensch S, Osselaer S, Talloen W, Van den Wyngaert I, Van Hecke G, Wuyts D; QSTAR Consortium; Van Goethem F, Göhlmann HW. Verbist BM, et al. Among authors: van goethem f. Chem Res Toxicol. 2015 Oct 19;28(10):1914-25. doi: 10.1021/acs.chemrestox.5b00103. Epub 2015 Sep 15. Chem Res Toxicol. 2015. PMID: 26313431 Free article.
Cosmetics Europe multi-laboratory pre-validation of the SkinEthic™ reconstituted human corneal epithelium test method for the prediction of eye irritation.
Alépée N, Bessou-Touya S, Cotovio J, de Smedt A, de Wever B, Faller C, Jones P, Le Varlet B, Marrec-Fairley M, Pfannenbecker U, Tailhardat M, van Goethem F, McNamee P. Alépée N, et al. Among authors: van goethem f. Toxicol In Vitro. 2013 Aug;27(5):1476-88. doi: 10.1016/j.tiv.2013.02.009. Epub 2013 Mar 20. Toxicol In Vitro. 2013. PMID: 23524228
Flow cytometric 96-well microplate-based in vitro micronucleus assay with human TK6 cells: protocol optimization and transferability assessment.
Bryce SM, Avlasevich SL, Bemis JC, Tate M, Walmsley RM, Saad F, Van Dijck K, De Boeck M, Van Goethem F, Lukamowicz-Rajska M, Elhajouji A, Dertinger SD. Bryce SM, et al. Among authors: van goethem f. Environ Mol Mutagen. 2013 Apr;54(3):180-94. doi: 10.1002/em.21760. Epub 2013 Feb 27. Environ Mol Mutagen. 2013. PMID: 23447390
Cosmetics Europe multi-laboratory pre-validation of the EpiOcular™ reconstituted human tissue test method for the prediction of eye irritation.
Pfannenbecker U, Bessou-Touya S, Faller C, Harbell J, Jacob T, Raabe H, Tailhardat M, Alépée N, De Smedt A, De Wever B, Jones P, Kaluzhny Y, Le Varlet B, McNamee P, Marrec-Fairley M, Van Goethem F. Pfannenbecker U, et al. Among authors: van goethem f. Toxicol In Vitro. 2013 Mar;27(2):619-26. doi: 10.1016/j.tiv.2012.11.007. Epub 2012 Nov 16. Toxicol In Vitro. 2013. PMID: 23159500
28 results