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Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans.
Fletcher SC, Hall C, Kennedy TJ, Pajusalu S, Wojcik MH, Boora U, Li C, Oja KT, Hendrix E, Westrip CA, Andrijes R, Piasecka SK, Singh M, El-Asrag ME, Ptasinska A, Tillmann V, Higgs MR, Carere DA, Beggs AD, Pappas J, Rabin R, Smerdon SJ, Stewart GS, Õunap K, Coleman ML. Fletcher SC, et al. Among authors: andrijes r. J Clin Invest. 2023 Apr 3;133(7):e152784. doi: 10.1172/JCI152784. J Clin Invest. 2023. PMID: 36795492 Free PMC article.
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
Nowak RP, Tumber A, Hendrix E, Ansari MSZ, Sabatino M, Antonini L, Andrijes R, Salah E, Mautone N, Pellegrini FR, Simelis K, Kawamura A, Johansson C, Passeri D, Pellicciari R, Ciogli A, Del Bufalo D, Ragno R, Coleman ML, Trisciuoglio D, Mai A, Oppermann U, Schofield CJ, Rotili D. Nowak RP, et al. Among authors: andrijes r. J Med Chem. 2021 Dec 9;64(23):17031-17050. doi: 10.1021/acs.jmedchem.1c00605. Epub 2021 Nov 29. J Med Chem. 2021. PMID: 34843649 Free PMC article.
Tetraspanin 6 is a regulator of carcinogenesis in colorectal cancer.
Andrijes R, Hejmadi RK, Pugh M, Rajesh S, Novitskaya V, Ibrahim M, Overduin M, Tselepis C, Middleton GW, Győrffy B, Beggs AD, Berditchevski F. Andrijes R, et al. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2011411118. doi: 10.1073/pnas.2011411118. Proc Natl Acad Sci U S A. 2021. PMID: 34521767 Free PMC article.
The CD151-midkine pathway regulates the immune microenvironment in inflammatory breast cancer.
Hayward S, Gachehiladze M, Badr N, Andrijes R, Molostvov G, Paniushkina L, Sopikova B, Slobodová Z, Mgebrishvili G, Sharma N, Horimoto Y, Burg D, Robertson G, Hanby A, Hoar F, Rea D, Eckhardt BL, Ueno NT, Nazarenko I, Long HM, van Laere S, Shaaban AM, Berditchevski F. Hayward S, et al. Among authors: andrijes r. J Pathol. 2020 May;251(1):63-73. doi: 10.1002/path.5415. Epub 2020 Mar 24. J Pathol. 2020. PMID: 32129471