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Page 1
Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans.
Fletcher SC, Hall C, Kennedy TJ, Pajusalu S, Wojcik MH, Boora U, Li C, Oja KT, Hendrix E, Westrip CA, Andrijes R, Piasecka SK, Singh M, El-Asrag ME, Ptasinska A, Tillmann V, Higgs MR, Carere DA, Beggs AD, Pappas J, Rabin R, Smerdon SJ, Stewart GS, Õunap K, Coleman ML. Fletcher SC, et al. Among authors: smerdon sj. J Clin Invest. 2023 Apr 3;133(7):e152784. doi: 10.1172/JCI152784. J Clin Invest. 2023. PMID: 36795492 Free PMC article.
RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1.
Abu-Libdeh B, Jhujh SS, Dhar S, Sommers JA, Datta A, Longo GM, Grange LJ, Reynolds JJ, Cooke SL, McNee GS, Hollingworth R, Woodward BL, Ganesh AN, Smerdon SJ, Nicolae CM, Durlacher-Betzer K, Molho-Pessach V, Abu-Libdeh A, Meiner V, Moldovan GL, Roukos V, Harel T, Brosh RM Jr, Stewart GS. Abu-Libdeh B, et al. Among authors: smerdon sj. J Clin Invest. 2022 Mar 1;132(5):e147301. doi: 10.1172/JCI147301. J Clin Invest. 2022. PMID: 35025765 Free PMC article.
Uncoupling conformational states from activity in an allosteric enzyme.
Pisco JP, de Chiara C, Pacholarz KJ, Garza-Garcia A, Ogrodowicz RW, Walker PA, Barran PE, Smerdon SJ, de Carvalho LPS. Pisco JP, et al. Among authors: smerdon sj. Nat Commun. 2017 Aug 7;8(1):203. doi: 10.1038/s41467-017-00224-0. Nat Commun. 2017. PMID: 28781362 Free PMC article.
MRE11 stability is regulated by CK2-dependent interaction with R2TP complex.
von Morgen P, Burdova K, Flower TG, O'Reilly NJ, Boulton SJ, Smerdon SJ, Macurek L, Hořejší Z. von Morgen P, et al. Among authors: smerdon sj. Oncogene. 2017 Aug 24;36(34):4943-4950. doi: 10.1038/onc.2017.99. Epub 2017 Apr 24. Oncogene. 2017. PMID: 28436950 Free PMC article.
HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization.
Raz R, Burlina F, Ismail M, Downward J, Li J, Smerdon SJ, Quibell M, White PD, Offer J. Raz R, et al. Among authors: smerdon sj. Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13174-13179. doi: 10.1002/anie.201607657. Angew Chem Int Ed Engl. 2016. PMID: 27654901 Free PMC article.
Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.
Martino L, Pennell S, Kelly G, Busi B, Brown P, Atkinson RA, Salisbury NJ, Ooi ZH, See KW, Smerdon SJ, Alfano C, Bui TT, Conte MR. Martino L, et al. Among authors: smerdon sj. Nucleic Acids Res. 2015 Jan;43(1):645-60. doi: 10.1093/nar/gku1287. Epub 2014 Dec 8. Nucleic Acids Res. 2015. PMID: 25488812 Free PMC article.
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage.
Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo LI, Fink D, Rask MB, Grøfte M, Lukas C, Nielsen ML, Smerdon SJ, Lukas J, Stucki M. Larsen DH, et al. Among authors: smerdon sj. Nat Cell Biol. 2014 Aug;16(8):792-803. doi: 10.1038/ncb3007. Epub 2014 Jul 27. Nat Cell Biol. 2014. PMID: 25064736 Free PMC article.
97 results