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SGN-CD228A Is an Investigational CD228-Directed Antibody-Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models.
Mazahreh R, Mason ML, Gosink JJ, Olson DJ, Thurman R, Hale C, Westendorf L, Pires TA, Leiske CI, Carlson M, Nguyen LT, Cochran JH, Okeley NM, Yumul R, Jin S, Stone IJ, Sahetya D, Nesterova A, Allred S, Hensley KM, Hu R, Lawrence R, Lewis TS, Sandall S. Mazahreh R, et al. Among authors: cochran jh. Mol Cancer Ther. 2023 Apr 3;22(4):421-434. doi: 10.1158/1535-7163.MCT-22-0401. Mol Cancer Ther. 2023. PMID: 36800443 Free PMC article. Clinical Trial.
Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates.
Burke PJ, Hamilton JZ, Pires TA, Setter JR, Hunter JH, Cochran JH, Waight AB, Gordon KA, Toki BE, Emmerton KK, Zeng W, Stone IJ, Senter PD, Lyon RP, Jeffrey SC. Burke PJ, et al. Among authors: cochran jh. Mol Cancer Ther. 2016 May;15(5):938-45. doi: 10.1158/1535-7163.MCT-16-0038. Epub 2016 Mar 4. Mol Cancer Ther. 2016. PMID: 26944920
Development of Novel Antibody-Camptothecin Conjugates.
Lyski RD, Bou LB, Lau UY, Meyer DW, Cochran JH, Okeley NM, Emmerton KK, Zapata F, Simmons JK, Trueblood ES, Ortiz DJ, Zaval MC, Snead KM, Jin S, Farr LM, Ryan MC, Senter PD, Jeffrey SC. Lyski RD, et al. Among authors: cochran jh. Mol Cancer Ther. 2021 Feb;20(2):329-339. doi: 10.1158/1535-7163.MCT-20-0526. Epub 2020 Dec 3. Mol Cancer Ther. 2021. PMID: 33273058
Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates.
Neumann CS, Olivas KC, Anderson ME, Cochran JH, Jin S, Li F, Loftus LV, Meyer DW, Neale J, Nix JC, Pittman PG, Simmons JK, Ulrich ML, Waight AB, Wong A, Zaval MC, Zeng W, Lyon RP, Senter PD. Neumann CS, et al. Among authors: cochran jh. Mol Cancer Ther. 2018 Dec;17(12):2633-2642. doi: 10.1158/1535-7163.MCT-18-0643. Epub 2018 Sep 21. Mol Cancer Ther. 2018. PMID: 30242091
A coiled-coil masking domain for selective activation of therapeutic antibodies.
Trang VH, Zhang X, Yumul RC, Zeng W, Stone IJ, Wo SW, Dominguez MM, Cochran JH, Simmons JK, Ryan MC, Lyon RP, Senter PD, Levengood MR. Trang VH, et al. Among authors: cochran jh. Nat Biotechnol. 2019 Jul;37(7):761-765. doi: 10.1038/s41587-019-0135-x. Epub 2019 May 27. Nat Biotechnol. 2019. PMID: 31133742
30 results