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SGN-CD228A Is an Investigational CD228-Directed Antibody-Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models.
Mol Cancer Ther. 2023 Apr 3;22(4):421-434. doi: 10.1158/1535-7163.MCT-22-0401.
Mol Cancer Ther. 2023.
PMID: 36800443
Free PMC article.
Clinical Trial.
HER2-Selective and Reversible Tyrosine Kinase Inhibitor Tucatinib Potentiates the Activity of T-DM1 in Preclinical Models of HER2-positive Breast Cancer.
Olson D, Taylor J, Willis K, Hensley K, Allred S, Zaval M, Farr L, Thurman R, Jain N, Hein R, Ulrich M, Peterson S, Kulukian A.
Olson D, et al.
Cancer Res Commun. 2023 Sep 25;3(9):1927-1939. doi: 10.1158/2767-9764.CRC-23-0302.
Cancer Res Commun. 2023.
PMID: 37721518
Free PMC article.
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SGN-B7H4V, an investigational vedotin ADC directed to the immune checkpoint ligand B7-H4, shows promising activity in preclinical models.
Gray E, Ulrich M, Epp A, Younan P, Sahetya D, Hensley K, Allred S, Huang LY, Hahn J, Gahnberg K, Treuting PM, Trueblood ES, Gosink JJ, Thurman R, Wo S, Spahr K, Haass EJ, Snead K, Miller D, Padilla M, Smith AJ, Frantz C, Schrum JP, Nazarenko N, Gardai SJ.
Gray E, et al.
J Immunother Cancer. 2023 Oct;11(10):e007572. doi: 10.1136/jitc-2023-007572.
J Immunother Cancer. 2023.
PMID: 37793853
Free PMC article.
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Off-target platelet activation in macaques unique to a therapeutic monoclonal antibody.
Santostefano MJ, Kirchner J, Vissinga C, Fort M, Lear S, Pan WJ, Prince PJ, Hensley KM, Tran D, Rock D, Vargas HM, Narayanan P, Jawando R, Rees W, Reindel JF, Reynhardt K, Everds N.
Santostefano MJ, et al. Among authors: hensley km.
Toxicol Pathol. 2012 Aug;40(6):899-917. doi: 10.1177/0192623312444029. Epub 2012 May 2.
Toxicol Pathol. 2012.
PMID: 22552394
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