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SGN-CD228A Is an Investigational CD228-Directed Antibody-Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models.
Mazahreh R, Mason ML, Gosink JJ, Olson DJ, Thurman R, Hale C, Westendorf L, Pires TA, Leiske CI, Carlson M, Nguyen LT, Cochran JH, Okeley NM, Yumul R, Jin S, Stone IJ, Sahetya D, Nesterova A, Allred S, Hensley KM, Hu R, Lawrence R, Lewis TS, Sandall S. Mazahreh R, et al. Among authors: yumul r. Mol Cancer Ther. 2023 Apr 3;22(4):421-434. doi: 10.1158/1535-7163.MCT-22-0401. Mol Cancer Ther. 2023. PMID: 36800443 Free PMC article. Clinical Trial.
A coiled-coil masking domain for selective activation of therapeutic antibodies.
Trang VH, Zhang X, Yumul RC, Zeng W, Stone IJ, Wo SW, Dominguez MM, Cochran JH, Simmons JK, Ryan MC, Lyon RP, Senter PD, Levengood MR. Trang VH, et al. Among authors: yumul rc. Nat Biotechnol. 2019 Jul;37(7):761-765. doi: 10.1038/s41587-019-0135-x. Epub 2019 May 27. Nat Biotechnol. 2019. PMID: 31133742
Epithelial junction opener JO-1 improves monoclonal antibody therapy of cancer.
Beyer I, van Rensburg R, Strauss R, Li Z, Wang H, Persson J, Yumul R, Feng Q, Song H, Bartek J, Fender P, Lieber A. Beyer I, et al. Among authors: yumul r. Cancer Res. 2011 Nov 15;71(22):7080-90. doi: 10.1158/0008-5472.CAN-11-2009. Epub 2011 Oct 11. Cancer Res. 2011. PMID: 21990319 Free PMC article.
Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models.
Liu Y, Tuve S, Persson J, Beyer I, Yumul R, Li ZY, Tragoolpua K, Hellström KE, Roffler S, Lieber A. Liu Y, et al. Among authors: yumul r. Cancer Gene Ther. 2011 Jun;18(6):407-18. doi: 10.1038/cgt.2011.8. Epub 2011 Mar 11. Cancer Gene Ther. 2011. PMID: 21394107 Free PMC article.
Preclinical safety, pharmacokinetics, pharmacodynamics, and biodistribution studies with Ad35K++ protein: a novel rituximab cotherapeutic.
Richter M, Yumul R, Saydaminova K, Wang H, Gough M, Baldessari A, Cattaneo R, Lee F, Wang CH, Jang H, Astier A, Gopal A, Carter D, Lieber A. Richter M, et al. Among authors: yumul r. Mol Ther Methods Clin Dev. 2016 Mar 30;5:16013. doi: 10.1038/mtm.2016.13. eCollection 2016. Mol Ther Methods Clin Dev. 2016. PMID: 27069950 Free PMC article.
66 results