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Hallmarks of neurodegenerative diseases.
Wilson DM 3rd, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I. Wilson DM 3rd, et al. Among authors: holtzman dm. Cell. 2023 Feb 16;186(4):693-714. doi: 10.1016/j.cell.2022.12.032. Cell. 2023. PMID: 36803602 Free article. Review.
APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread.
Chen Y, Song S, Parhizkar S, Lord J, Zhu Y, Strickland MR, Wang C, Park J, Tabor GT, Jiang H, Li K, Davis AA, Yuede CM, Colonna M, Ulrich JD, Holtzman DM. Chen Y, et al. Among authors: holtzman dm. Cell. 2024 Jan 18;187(2):428-445.e20. doi: 10.1016/j.cell.2023.11.029. Epub 2023 Dec 11. Cell. 2024. PMID: 38086389
Tauopathy severely disrupts homeostatic set-points in emergent neural dynamics but not in the activity of individual neurons.
McGregor JN, Farris CA, Ensley S, Schneider A, Wang C, Liu Y, Tu J, Elmore H, Ronayne KD, Wessel R, Dyer EL, Bhaskaran-Nair K, Holtzman DM, Hengen KB. McGregor JN, et al. Among authors: holtzman dm. bioRxiv [Preprint]. 2023 Sep 6:2023.09.01.555947. doi: 10.1101/2023.09.01.555947. bioRxiv. 2023. PMID: 37732214 Free PMC article. Preprint.
Insights from new in vivo models of TREM2 variants.
Jain N, Holtzman DM. Jain N, et al. Among authors: holtzman dm. Mol Neurodegener. 2023 Apr 5;18(1):21. doi: 10.1186/s13024-023-00609-4. Mol Neurodegener. 2023. PMID: 37016433 Free PMC article. No abstract available.
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist.
Litvinchuk A, Suh JH, Guo JL, Lin K, Davis SS, Bien-Ly N, Tycksen E, Tabor GT, Remolina Serrano J, Manis M, Bao X, Lee C, Bosch M, Perez EJ, Yuede CM, Cashikar AG, Ulrich JD, Di Paolo G, Holtzman DM. Litvinchuk A, et al. Among authors: holtzman dm. Neuron. 2024 Feb 7;112(3):384-403.e8. doi: 10.1016/j.neuron.2023.10.023. Epub 2023 Nov 22. Neuron. 2024. PMID: 37995685
610 results