Mitsuya H - Search Results

1

Identification of SARS-CoV-2 M^pro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2.

Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T, Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori SI, Das D, Uemura Y, Shimizu Y, Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y, Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y, Tamamura H, Mitsuya H. Higashi-Kuwata N, et al. Among authors: mitsuya h. Nat Commun. 2023 Feb 25;14(1):1076. doi: 10.1038/s41467-023-36729-0. Nat Commun. 2023. PMID: 36841831 Free PMC article.

2

Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of its in vitro antiretroviral activity in the presence of high concentrations of proteins.

Kageyama S, Anderson BD, Hoesterey BL, Hayashi H, Kiso Y, Flora KP, Mitsuya H. Kageyama S, et al. Among authors: mitsuya h. Antimicrob Agents Chemother. 1994 May;38(5):1107-11. doi: 10.1128/AAC.38.5.1107. Antimicrob Agents Chemother. 1994. PMID: 8067746 Free PMC article.

3

In vitro anti-human immunodeficiency virus activities of Z- and E-methylenecyclopropane nucleoside analogues and their phosphoro-L-alaninate diesters.

Uchida H, Kodama EN, Yoshimura K, Maeda Y, Kosalaraksa P, Maroun V, Qiu YL, Zemlicka J, Mitsuya H. Uchida H, et al. Among authors: mitsuya h. Antimicrob Agents Chemother. 1999 Jun;43(6):1487-90. doi: 10.1128/AAC.43.6.1487. Antimicrob Agents Chemother. 1999. PMID: 10348777 Free PMC article.

4

JE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1.

Yoshimura K, Kato R, Yusa K, Kavlick MF, Maroun V, Nguyen A, Mimoto T, Ueno T, Shintani M, Falloon J, Masur H, Hayashi H, Erickson J, Mitsuya H. Yoshimura K, et al. Among authors: mitsuya h. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8675-80. doi: 10.1073/pnas.96.15.8675. Proc Natl Acad Sci U S A. 1999. PMID: 10411934 Free PMC article.

5

In vitro induction of human immunodeficiency virus type 1 variants resistant to phosphoralaninate prodrugs of Z-methylenecyclopropane nucleoside analogues.

Yoshimura K, Feldman R, Kodama E, Kavlick MF, Qiu YL, Zemlicka J, Mitsuya H. Yoshimura K, et al. Among authors: mitsuya h. Antimicrob Agents Chemother. 1999 Oct;43(10):2479-83. doi: 10.1128/AAC.43.10.2479. Antimicrob Agents Chemother. 1999. PMID: 10508028 Free PMC article.

6

Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5.

Maeda K, Yoshimura K, Shibayama S, Habashita H, Tada H, Sagawa K, Miyakawa T, Aoki M, Fukushima D, Mitsuya H. Maeda K, et al. Among authors: mitsuya h. J Biol Chem. 2001 Sep 14;276(37):35194-200. doi: 10.1074/jbc.M105670200. Epub 2001 Jul 13. J Biol Chem. 2001. PMID: 11454872 Free article.

7

Identification of amino acid residues critical for LD78beta, a variant of human macrophage inflammatory protein-1alpha, binding to CCR5 and inhibition of R5 human immunodeficiency virus type 1 replication.

Miyakawa T, Obaru K, Maeda K, Harada S, Mitsuya H. Miyakawa T, et al. Among authors: mitsuya h. J Biol Chem. 2002 Feb 15;277(7):4649-55. doi: 10.1074/jbc.M109198200. Epub 2001 Dec 4. J Biol Chem. 2002. PMID: 11734558 Free article.

8

Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors.

Gatanaga H, Suzuki Y, Tsang H, Yoshimura K, Kavlick MF, Nagashima K, Gorelick RJ, Mardy S, Tang C, Summers MF, Mitsuya H. Gatanaga H, et al. Among authors: mitsuya h. J Biol Chem. 2002 Feb 22;277(8):5952-61. doi: 10.1074/jbc.M108005200. Epub 2001 Dec 10. J Biol Chem. 2002. PMID: 11741936 Free article.

9

A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site.

Yoshimura K, Kato R, Kavlick MF, Nguyen A, Maroun V, Maeda K, Hussain KA, Ghosh AK, Gulnik SV, Erickson JW, Mitsuya H. Yoshimura K, et al. Among authors: mitsuya h. J Virol. 2002 Feb;76(3):1349-58. doi: 10.1128/jvi.76.3.1349-1358.2002. J Virol. 2002. PMID: 11773409 Free PMC article.

10

Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains.

Tamamura H, Koh Y, Ueda S, Sasaki Y, Yamasaki T, Aoki M, Maeda K, Watai Y, Arikuni H, Otaka A, Mitsuya H, Fujii N. Tamamura H, et al. Among authors: mitsuya h. J Med Chem. 2003 Apr 24;46(9):1764-8. doi: 10.1021/jm020537i. J Med Chem. 2003. PMID: 12699395

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