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Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2.
Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T, Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori SI, Das D, Uemura Y, Shimizu Y, Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y, Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y, Tamamura H, Mitsuya H. Higashi-Kuwata N, et al. Among authors: ogata aoki h. Nat Commun. 2023 Feb 25;14(1):1076. doi: 10.1038/s41467-023-36729-0. Nat Commun. 2023. PMID: 36841831 Free PMC article.
Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV.
Higashi-Kuwata N, Hayashi S, Kumamoto H, Ogata-Aoki H, Das D, Venzon D, Hattori SI, Bulut H, Hashimoto M, Otagiri M, Takamune N, Kishimoto N, Davis DA, Misumi S, Kakuni M, Tanaka Y, Mitsuya H. Higashi-Kuwata N, et al. Among authors: ogata aoki h. J Hepatol. 2021 May;74(5):1075-1086. doi: 10.1016/j.jhep.2020.12.006. Epub 2020 Dec 15. J Hepatol. 2021. PMID: 33333207 Free PMC article.
Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1JR-FL in the setting of post-exposure prophylaxis in NOD/SCID/Jak3-/- mice transplanted with human PBMCs.
Ogata-Aoki H, Higashi-Kuwata N, Hattori SI, Hayashi H, Danish M, Aoki M, Shiotsu C, Hashiguchi Y, Hamada A, Kobayashi H, Ihn H, Okada S, Mitsuya H. Ogata-Aoki H, et al. Antiviral Res. 2018 Jan;149:78-88. doi: 10.1016/j.antiviral.2017.09.003. Epub 2017 Sep 8. Antiviral Res. 2018. PMID: 28893602 Free PMC article.
Involvement of the second extracellular loop and transmembrane residues of CCR5 in inhibitor binding and HIV-1 fusion: insights into the mechanism of allosteric inhibition.
Maeda K, Das D, Yin PD, Tsuchiya K, Ogata-Aoki H, Nakata H, Norman RB, Hackney LA, Takaoka Y, Mitsuya H. Maeda K, et al. Among authors: ogata aoki h. J Mol Biol. 2008 Sep 12;381(4):956-74. doi: 10.1016/j.jmb.2008.06.041. Epub 2008 Jun 20. J Mol Biol. 2008. PMID: 18590744 Free PMC article.
Early phase dynamics of traceable mCherry fluorescent protein-carrying HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3-/- mice.
Higashi-Kuwata N, Ogata-Aoki H, Hattori SI, Hayashi H, Danish M, Aoki M, Shiotsu C, Kawamura T, Ihn H, Kobayashi H, Okada S, Mitsuya H. Higashi-Kuwata N, et al. Among authors: ogata aoki h. Antiviral Res. 2017 Aug;144:83-92. doi: 10.1016/j.antiviral.2017.03.027. Epub 2017 Apr 7. Antiviral Res. 2017. PMID: 28392419 Free PMC article.
Structural and molecular interactions of CCR5 inhibitors with CCR5.
Maeda K, Das D, Ogata-Aoki H, Nakata H, Miyakawa T, Tojo Y, Norman R, Takaoka Y, Ding J, Arnold GF, Arnold E, Mitsuya H. Maeda K, et al. Among authors: ogata aoki h. J Biol Chem. 2006 May 5;281(18):12688-98. doi: 10.1074/jbc.M512688200. Epub 2006 Feb 13. J Biol Chem. 2006. PMID: 16476734 Free article.
GRL-02031, a novel nonpeptidic protease inhibitor (PI) containing a stereochemically defined fused cyclopentanyltetrahydrofuran potent against multi-PI-resistant human immunodeficiency virus type 1 in vitro.
Koh Y, Das D, Leschenko S, Nakata H, Ogata-Aoki H, Amano M, Nakayama M, Ghosh AK, Mitsuya H. Koh Y, et al. Among authors: ogata aoki h. Antimicrob Agents Chemother. 2009 Mar;53(3):997-1006. doi: 10.1128/AAC.00689-08. Epub 2008 Oct 27. Antimicrob Agents Chemother. 2009. PMID: 18955518 Free PMC article.