Tamamura H - Search Results

1

Identification of SARS-CoV-2 M^pro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2.

Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T, Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori SI, Das D, Uemura Y, Shimizu Y, Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y, Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y, Tamamura H, Mitsuya H. Higashi-Kuwata N, et al. Among authors: tamamura h. Nat Commun. 2023 Feb 25;14(1):1076. doi: 10.1038/s41467-023-36729-0. Nat Commun. 2023. PMID: 36841831 Free PMC article.

2

Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains.

Tamamura H, Koh Y, Ueda S, Sasaki Y, Yamasaki T, Aoki M, Maeda K, Watai Y, Arikuni H, Otaka A, Mitsuya H, Fujii N. Tamamura H, et al. J Med Chem. 2003 Apr 24;46(9):1764-8. doi: 10.1021/jm020537i. J Med Chem. 2003. PMID: 12699395

3

HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus.

Yamamoto N, Yang R, Yoshinaka Y, Amari S, Nakano T, Cinatl J, Rabenau H, Doerr HW, Hunsmann G, Otaka A, Tamamura H, Fujii N, Yamamoto N. Yamamoto N, et al. Among authors: tamamura h. Biochem Biophys Res Commun. 2004 Jun 4;318(3):719-25. doi: 10.1016/j.bbrc.2004.04.083. Biochem Biophys Res Commun. 2004. PMID: 15144898 Free PMC article.

4

Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs.

Nakata H, Steinberg SM, Koh Y, Maeda K, Takaoka Y, Tamamura H, Fujii N, Mitsuya H. Nakata H, et al. Among authors: tamamura h. Antimicrob Agents Chemother. 2008 Jun;52(6):2111-9. doi: 10.1128/AAC.01299-07. Epub 2008 Mar 31. Antimicrob Agents Chemother. 2008. PMID: 18378711 Free PMC article.

5

CD4 mimics targeting the mechanism of HIV entry.

Yamada Y, Ochiai C, Yoshimura K, Tanaka T, Ohashi N, Narumi T, Nomura W, Harada S, Matsushita S, Tamamura H. Yamada Y, et al. Among authors: tamamura h. Bioorg Med Chem Lett. 2010 Jan 1;20(1):354-8. doi: 10.1016/j.bmcl.2009.10.098. Epub 2009 Nov 4. Bioorg Med Chem Lett. 2010. PMID: 19926478

6

Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds.

Yoshimura K, Harada S, Shibata J, Hatada M, Yamada Y, Ochiai C, Tamamura H, Matsushita S. Yoshimura K, et al. Among authors: tamamura h. J Virol. 2010 Aug;84(15):7558-68. doi: 10.1128/JVI.00227-10. Epub 2010 May 26. J Virol. 2010. PMID: 20504942 Free PMC article.

7

CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist.

Narumi T, Ochiai C, Yoshimura K, Harada S, Tanaka T, Nomura W, Arai H, Ozaki T, Ohashi N, Matsushita S, Tamamura H. Narumi T, et al. Among authors: tamamura h. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5853-8. doi: 10.1016/j.bmcl.2010.07.106. Epub 2010 Aug 3. Bioorg Med Chem Lett. 2010. PMID: 20728351

8

Small molecular CD4 mimics as HIV entry inhibitors.

Narumi T, Arai H, Yoshimura K, Harada S, Nomura W, Matsushita S, Tamamura H. Narumi T, et al. Among authors: tamamura h. Bioorg Med Chem. 2011 Nov 15;19(22):6735-42. doi: 10.1016/j.bmc.2011.09.045. Epub 2011 Sep 29. Bioorg Med Chem. 2011. PMID: 22014753

9

Stereoselective formation of trisubstituted (Z)-chloroalkenes adjacent to a tertiary carbon stereogenic center by organocuprate-mediated reduction/alkylation.

Narumi T, Kobayakawa T, Aikawa H, Seike S, Tamamura H. Narumi T, et al. Among authors: tamamura h. Org Lett. 2012 Sep 7;14(17):4490-3. doi: 10.1021/ol301988d. Epub 2012 Aug 17. Org Lett. 2012. PMID: 22900591

10

CD4 mimics as HIV entry inhibitors: lead optimization studies of the aromatic substituents.

Narumi T, Arai H, Yoshimura K, Harada S, Hirota Y, Ohashi N, Hashimoto C, Nomura W, Matsushita S, Tamamura H. Narumi T, et al. Among authors: tamamura h. Bioorg Med Chem. 2013 May 1;21(9):2518-26. doi: 10.1016/j.bmc.2013.02.041. Epub 2013 Mar 7. Bioorg Med Chem. 2013. PMID: 23535561

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