Yoshimura K - Search Results

1

Identification of SARS-CoV-2 M^pro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2.

Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T, Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori SI, Das D, Uemura Y, Shimizu Y, Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y, Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y, Tamamura H, Mitsuya H. Higashi-Kuwata N, et al. Among authors: yoshimura k. Nat Commun. 2023 Feb 25;14(1):1076. doi: 10.1038/s41467-023-36729-0. Nat Commun. 2023. PMID: 36841831 Free PMC article.

2

Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors.

Gatanaga H, Suzuki Y, Tsang H, Yoshimura K, Kavlick MF, Nagashima K, Gorelick RJ, Mardy S, Tang C, Summers MF, Mitsuya H. Gatanaga H, et al. Among authors: yoshimura k. J Biol Chem. 2002 Feb 22;277(8):5952-61. doi: 10.1074/jbc.M108005200. Epub 2001 Dec 10. J Biol Chem. 2002. PMID: 11741936 Free article.

3

A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site.

Yoshimura K, Kato R, Kavlick MF, Nguyen A, Maroun V, Maeda K, Hussain KA, Ghosh AK, Gulnik SV, Erickson JW, Mitsuya H. Yoshimura K, et al. J Virol. 2002 Feb;76(3):1349-58. doi: 10.1128/jvi.76.3.1349-1358.2002. J Virol. 2002. PMID: 11773409 Free PMC article.

4

[New HIV-1 protease inhibitors in development].

Yoshimura K, Maeda K. Yoshimura K, et al. Nihon Rinsho. 2002 Apr;60(4):780-3. Nihon Rinsho. 2002. PMID: 11968788 Review. Japanese.

5

The impact of highly active antiretroviral therapy by the oral route on the CD8 subset in monkeys infected chronically with SHIV 89.6P.

Yoshimura K, Ido E, Akiyama H, Kimura T, Aoki M, Suzuki H, Mitsuya H, Hayami M, Matsushita S. Yoshimura K, et al. J Virol Methods. 2003 Sep;112(1-2):121-8. doi: 10.1016/s0166-0934(03)00201-5. J Virol Methods. 2003. PMID: 12951220

6

Inhibition of HIV-1 replication by a peptide dimerization inhibitor of HIV-1 protease.

Davis DA, Brown CA, Singer KE, Wang V, Kaufman J, Stahl SJ, Wingfield P, Maeda K, Harada S, Yoshimura K, Kosalaraksa P, Mitsuya H, Yarchoan R. Davis DA, et al. Among authors: yoshimura k. Antiviral Res. 2006 Nov;72(2):89-99. doi: 10.1016/j.antiviral.2006.03.015. Epub 2006 Apr 21. Antiviral Res. 2006. PMID: 16687179

7

Resistance profile of a neutralizing anti-HIV monoclonal antibody, KD-247, that shows favourable synergism with anti-CCR5 inhibitors.

Yoshimura K, Shibata J, Kimura T, Honda A, Maeda Y, Koito A, Murakami T, Mitsuya H, Matsushita S. Yoshimura K, et al. AIDS. 2006 Oct 24;20(16):2065-73. doi: 10.1097/01.aids.0000247587.31320.fe. AIDS. 2006. PMID: 17053352

8

Non-cleavage site gag mutations in amprenavir-resistant human immunodeficiency virus type 1 (HIV-1) predispose HIV-1 to rapid acquisition of amprenavir resistance but delay development of resistance to other protease inhibitors.

Aoki M, Venzon DJ, Koh Y, Aoki-Ogata H, Miyakawa T, Yoshimura K, Maeda K, Mitsuya H. Aoki M, et al. Among authors: yoshimura k. J Virol. 2009 Apr;83(7):3059-68. doi: 10.1128/JVI.02539-08. Epub 2009 Jan 28. J Virol. 2009. PMID: 19176623 Free PMC article.

9

CD4 mimics targeting the mechanism of HIV entry.

Yamada Y, Ochiai C, Yoshimura K, Tanaka T, Ohashi N, Narumi T, Nomura W, Harada S, Matsushita S, Tamamura H. Yamada Y, et al. Among authors: yoshimura k. Bioorg Med Chem Lett. 2010 Jan 1;20(1):354-8. doi: 10.1016/j.bmcl.2009.10.098. Epub 2009 Nov 4. Bioorg Med Chem Lett. 2010. PMID: 19926478

10

Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds.

Yoshimura K, Harada S, Shibata J, Hatada M, Yamada Y, Ochiai C, Tamamura H, Matsushita S. Yoshimura K, et al. J Virol. 2010 Aug;84(15):7558-68. doi: 10.1128/JVI.00227-10. Epub 2010 May 26. J Virol. 2010. PMID: 20504942 Free PMC article.

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