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Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects.
Jain S, Rick JW, Joshi RS, Beniwal A, Spatz J, Gill S, Chang AC, Choudhary N, Nguyen AT, Sudhir S, Chalif EJ, Chen JS, Chandra A, Haddad AF, Wadhwa H, Shah SS, Choi S, Hayes JL, Wang L, Yagnik G, Costello JF, Diaz A, Heiland DH, Aghi MK. Jain S, et al. Among authors: diaz a. J Clin Invest. 2023 Mar 1;133(5):e147087. doi: 10.1172/JCI147087. J Clin Invest. 2023. PMID: 36856115 Free PMC article.
Recurrent epimutations activate gene body promoters in primary glioblastoma.
Nagarajan RP, Zhang B, Bell RJ, Johnson BE, Olshen AB, Sundaram V, Li D, Graham AE, Diaz A, Fouse SD, Smirnov I, Song J, Paris PL, Wang T, Costello JF. Nagarajan RP, et al. Among authors: diaz a. Genome Res. 2014 May;24(5):761-74. doi: 10.1101/gr.164707.113. Epub 2014 Apr 7. Genome Res. 2014. PMID: 24709822 Free PMC article.
Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment.
Müller S, Kohanbash G, Liu SJ, Alvarado B, Carrera D, Bhaduri A, Watchmaker PB, Yagnik G, Di Lullo E, Malatesta M, Amankulor NM, Kriegstein AR, Lim DA, Aghi M, Okada H, Diaz A. Müller S, et al. Among authors: diaz a. Genome Biol. 2017 Dec 20;18(1):234. doi: 10.1186/s13059-017-1362-4. Genome Biol. 2017. PMID: 29262845 Free PMC article.
The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation.
Wang L, Babikir H, Müller S, Yagnik G, Shamardani K, Catalan F, Kohanbash G, Alvarado B, Di Lullo E, Kriegstein A, Shah S, Wadhwa H, Chang SM, Phillips JJ, Aghi MK, Diaz AA. Wang L, et al. Among authors: diaz aa. Cancer Discov. 2019 Dec;9(12):1708-1719. doi: 10.1158/2159-8290.CD-19-0329. Epub 2019 Sep 25. Cancer Discov. 2019. PMID: 31554641 Free PMC article.
Clonal ZEB1-Driven Mesenchymal Transition Promotes Targetable Oncologic Antiangiogenic Therapy Resistance.
Chandra A, Jahangiri A, Chen W, Nguyen AT, Yagnik G, Pereira MP, Jain S, Garcia JH, Shah SS, Wadhwa H, Joshi RS, Weiss J, Wolf KJ, Lin JG, Müller S, Rick JW, Diaz AA, Gilbert LA, Kumar S, Aghi MK. Chandra A, et al. Among authors: diaz aa. Cancer Res. 2020 Apr 1;80(7):1498-1511. doi: 10.1158/0008-5472.CAN-19-1305. Epub 2020 Feb 10. Cancer Res. 2020. PMID: 32041837 Free PMC article.
Ensemble learning for classifying single-cell data and projection across reference atlases.
Wang L, Catalan F, Shamardani K, Babikir H, Diaz A. Wang L, et al. Among authors: diaz a. Bioinformatics. 2020 Jun 1;36(11):3585-3587. doi: 10.1093/bioinformatics/btaa137. Bioinformatics. 2020. PMID: 32105316 Free PMC article.
How best to project data across single-cell atlases is an open problem. We developed a boosted learner that overcomes the greatest challenge with status quo classifiers: low sensitivity, especially when dealing with rare cell types. ...AVAILABILITY AND IMPLEMENTATION: http …
How best to project data across single-cell atlases is an open problem. We developed a boosted learner that overcomes the greatest ch …
Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank.
Chuntova P, Chow F, Watchmaker PB, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ, Mitchell D, Terabe M, Wainwright DA, Berzofsky JA, Herold-Mende C, Heath JR, Lim M, Margolin KA, Chiocca EA, Kasahara N, Ellingson BM, Brown CE, Chen Y, Fecci PE, Reardon DA, Dunn GP, Liau LM, Costello JF, Wick W, Cloughesy T, Timmer WC, Wen PY, Prins RM, Platten M, Okada H. Chuntova P, et al. Among authors: diaz a. Neuro Oncol. 2021 Mar 25;23(3):356-375. doi: 10.1093/neuonc/noaa277. Neuro Oncol. 2021. PMID: 33367885 Free PMC article. Review.
The evolution of alternative splicing in glioblastoma under therapy.
Wang L, Shamardani K, Babikir H, Catalan F, Nejo T, Chang S, Phillips JJ, Okada H, Diaz AA. Wang L, et al. Among authors: diaz aa. Genome Biol. 2021 Jan 26;22(1):48. doi: 10.1186/s13059-021-02259-5. Genome Biol. 2021. PMID: 33499924 Free PMC article.
miRNA-independent function of long noncoding pri-miRNA loci.
He D, Wu D, Muller S, Wang L, Saha P, Ahanger SH, Liu SJ, Cui M, Hong SJ, Jain M, Olson HE, Akeson M, Costello JF, Diaz A, Lim DA. He D, et al. Among authors: diaz a. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2017562118. doi: 10.1073/pnas.2017562118. Proc Natl Acad Sci U S A. 2021. PMID: 33758101 Free PMC article.
3,112 results