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Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism.
Upadhyayula PS, Higgins DM, Mela A, Banu M, Dovas A, Zandkarimi F, Patel P, Mahajan A, Humala N, Nguyen TTT, Chaudhary KR, Liao L, Argenziano M, Sudhakar T, Sperring CP, Shapiro BL, Ahmed ER, Kinslow C, Ye LF, Siegelin MD, Cheng S, Soni R, Bruce JN, Stockwell BR, Canoll P. Upadhyayula PS, et al. Among authors: higgins dm. Nat Commun. 2023 Mar 2;14(1):1187. doi: 10.1038/s41467-023-36630-w. Nat Commun. 2023. PMID: 36864031 Free PMC article.
Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers.
Ye LF, Chaudhary KR, Zandkarimi F, Harken AD, Kinslow CJ, Upadhyayula PS, Dovas A, Higgins DM, Tan H, Zhang Y, Buonanno M, Wang TJC, Hei TK, Bruce JN, Canoll PD, Cheng SK, Stockwell BR. Ye LF, et al. Among authors: higgins dm. ACS Chem Biol. 2020 Feb 21;15(2):469-484. doi: 10.1021/acschembio.9b00939. Epub 2020 Jan 14. ACS Chem Biol. 2020. PMID: 31899616 Free PMC article.
Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial.
Spinazzi EF, Argenziano MG, Upadhyayula PS, Banu MA, Neira JA, Higgins DMO, Wu PB, Pereira B, Mahajan A, Humala N, Al-Dalahmah O, Zhao W, Save AV, Gill BJA, Boyett DM, Marie T, Furnari JL, Sudhakar TD, Stopka SA, Regan MS, Catania V, Good L, Zacharoulis S, Behl M, Petridis P, Jambawalikar S, Mintz A, Lignelli A, Agar NYR, Sims PA, Welch MR, Lassman AB, Iwamoto FM, D'Amico RS, Grinband J, Canoll P, Bruce JN. Spinazzi EF, et al. Among authors: higgins dmo. Lancet Oncol. 2022 Nov;23(11):1409-1418. doi: 10.1016/S1470-2045(22)00599-X. Epub 2022 Oct 13. Lancet Oncol. 2022. PMID: 36243020 Free PMC article. Clinical Trial.
A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma.
Banu MA, Dovas A, Argenziano MG, Zhao W, Grajal HC, Higgins DMO, Sperring CP, Pereira B, Ye LF, Mahajan A, Humala N, Furnari JL, Upadhyayula PS, Zandkarimi F, Nguyen TTT, Wu PB, Hai L, Karan C, Razavilar A, Siegelin MD, Kitajewski J, Bruce JN, Stockwell BR, Sims PA, Canoll PD. Banu MA, et al. bioRxiv [Preprint]. 2023 Feb 23:2023.02.22.529581. doi: 10.1101/2023.02.22.529581. bioRxiv. 2023. PMID: 36865302 Free PMC article. Preprint.
A multicenter analysis of the prognostic value of histone H3 K27M mutation in adult high-grade spinal glioma.
Akinduro OO, Garcia DP, Higgins DMO, Vivas-Buitrago T, Jentoft M, Solomon DA, Daniels DJ, Pennington Z, Sherman WJ, Delgardo M, Bydon M, Kalani MA, Zanazzi G, Tsankova N, Bendok BR, McCormick PC, Sciubba DM, Lo SL, Clarke JL, Abode-Iyamah K, Quiñones-Hinojosa A. Akinduro OO, et al. Among authors: higgins dmo. J Neurosurg Spine. 2021 Aug 20;35(6):834-843. doi: 10.3171/2021.2.SPINE201675. J Neurosurg Spine. 2021. PMID: 34416733
159 results