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Generation and structure-activity relationships of novel imidazo-thienopyridine based TLR7 agonists: application as payloads for immunostimulatory antibody drug-conjugates.
Brant MG, Garnett GAE, Guedia J, Lasalle M, Lawn S, Petersen ME, Duan R, Mendez-Campos J, Hirkala-Schaefer T, Winters GC, Barnscher SD. Brant MG, et al. Among authors: guedia j. Bioorg Med Chem Lett. 2023 Jul 15;91:129348. doi: 10.1016/j.bmcl.2023.129348. Epub 2023 May 20. Bioorg Med Chem Lett. 2023. PMID: 37217025
An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity.
Weisser NE, Sanches M, Escobar-Cabrera E, O'Toole J, Whalen E, Chan PWY, Wickman G, Abraham L, Choi K, Harbourne B, Samiotakis A, Rojas AH, Volkers G, Wong J, Atkinson CE, Baardsnes J, Worrall LJ, Browman D, Smith EE, Baichoo P, Cheng CW, Guedia J, Kang S, Mukhopadhyay A, Newhook L, Ohrn A, Raghunatha P, Zago-Schmitt M, Schrag JD, Smith J, Zwierzchowski P, Scurll JM, Fung V, Black S, Strynadka NCJ, Gold MR, Presta LG, Ng G, Dixit S. Weisser NE, et al. Among authors: guedia j. Nat Commun. 2023 Mar 13;14(1):1394. doi: 10.1038/s41467-023-37029-3. Nat Commun. 2023. PMID: 36914633 Free PMC article.