Sorger PK - Search Results

1

Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction.

Chen JY, Hug C, Reyes J, Tian C, Gerosa L, Fröhlich F, Ponsioen B, Snippert HJG, Spencer SL, Jambhekar A, Sorger PK, Lahav G. Chen JY, et al. Among authors: sorger pk. Cell Rep. 2023 Mar 28;42(3):112252. doi: 10.1016/j.celrep.2023.112252. Epub 2023 Mar 14. Cell Rep. 2023. PMID: 36920903 Free PMC article.

2

Modeling a snap-action, variable-delay switch controlling extrinsic cell death.

Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. Albeck JG, et al. Among authors: sorger pk. PLoS Biol. 2008 Dec 2;6(12):2831-52. doi: 10.1371/journal.pbio.0060299. PLoS Biol. 2008. PMID: 19053173 Free PMC article.

3

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis.

Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. Spencer SL, et al. Among authors: sorger pk. Nature. 2009 May 21;459(7245):428-32. doi: 10.1038/nature08012. Epub 2009 Apr 12. Nature. 2009. PMID: 19363473 Free PMC article.

4

Non-genetic cell-to-cell variability and the consequences for pharmacology.

Niepel M, Spencer SL, Sorger PK. Niepel M, et al. Among authors: sorger pk. Curr Opin Chem Biol. 2009 Dec;13(5-6):556-61. doi: 10.1016/j.cbpa.2009.09.015. Epub 2009 Oct 14. Curr Opin Chem Biol. 2009. PMID: 19833543 Free PMC article. Review.

5

Measuring and modeling apoptosis in single cells.

Spencer SL, Sorger PK. Spencer SL, et al. Among authors: sorger pk. Cell. 2011 Mar 18;144(6):926-39. doi: 10.1016/j.cell.2011.03.002. Cell. 2011. PMID: 21414484 Free PMC article. Review.

6

Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis.

Gaudet S, Spencer SL, Chen WW, Sorger PK. Gaudet S, et al. Among authors: sorger pk. PLoS Comput Biol. 2012;8(4):e1002482. doi: 10.1371/journal.pcbi.1002482. Epub 2012 Apr 26. PLoS Comput Biol. 2012. PMID: 22570596 Free PMC article.

7

Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes.

Flusberg DA, Roux J, Spencer SL, Sorger PK. Flusberg DA, et al. Among authors: sorger pk. Mol Biol Cell. 2013 Jul;24(14):2186-200. doi: 10.1091/mbc.E12-10-0737. Epub 2013 May 22. Mol Biol Cell. 2013. PMID: 23699397 Free PMC article.

8

Cyclic Immunofluorescence (CycIF), A Highly Multiplexed Method for Single-cell Imaging.

Lin JR, Fallahi-Sichani M, Chen JY, Sorger PK. Lin JR, et al. Among authors: sorger pk. Curr Protoc Chem Biol. 2016 Dec 7;8(4):251-264. doi: 10.1002/cpch.14. Curr Protoc Chem Biol. 2016. PMID: 27925668 Free PMC article.

9

Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.

Chopra SS, Jenney A, Palmer A, Niepel M, Chung M, Mills C, Sivakumaren SC, Liu Q, Chen JY, Yapp C, Asara JM, Gray NS, Sorger PK. Chopra SS, et al. Among authors: sorger pk. Cell Syst. 2020 Jan 22;10(1):66-81.e11. doi: 10.1016/j.cels.2019.11.001. Epub 2019 Dec 4. Cell Syst. 2020. PMID: 31812693 Free PMC article.

10

Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.

Gerosa L, Chidley C, Fröhlich F, Sanchez G, Lim SK, Muhlich J, Chen JY, Vallabhaneni S, Baker GJ, Schapiro D, Atanasova MI, Chylek LA, Shi T, Yi L, Nicora CD, Claas A, Ng TSC, Kohler RH, Lauffenburger DA, Weissleder R, Miller MA, Qian WJ, Wiley HS, Sorger PK. Gerosa L, et al. Among authors: sorger pk. Cell Syst. 2020 Nov 18;11(5):478-494.e9. doi: 10.1016/j.cels.2020.10.002. Epub 2020 Oct 27. Cell Syst. 2020. PMID: 33113355 Free PMC article.

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