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Machine Learning and Assay Development for Image-based Phenotypic Profiling of Drug Treatments.
Sexton JZ, Fursmidt R, O’Meara MJ, Omta W, Rao A, Egan DA, Haney SA. Sexton JZ, et al. Among authors: egan da. 2023 Mar 15. In: Markossian S, Grossman A, Arkin M, Auld D, Austin C, Baell J, Brimacombe K, Chung TDY, Coussens NP, Dahlin JL, Devanarayan V, Foley TL, Glicksman M, Gorshkov K, Haas JV, Hall MD, Hoare S, Inglese J, Iversen PW, Lal-Nag M, Li Z, Manro JR, McGee J, McManus O, Pearson M, Riss T, Saradjian P, Sittampalam GS, Tarselli M, Trask OJ Jr, Weidner JR, Wildey MJ, Wilson K, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004–. 2023 Mar 15. In: Markossian S, Grossman A, Arkin M, Auld D, Austin C, Baell J, Brimacombe K, Chung TDY, Coussens NP, Dahlin JL, Devanarayan V, Foley TL, Glicksman M, Gorshkov K, Haas JV, Hall MD, Hoare S, Inglese J, Iversen PW, Lal-Nag M, Li Z, Manro JR, McGee J, McManus O, Pearson M, Riss T, Saradjian P, Sittampalam GS, Tarselli M, Trask OJ Jr, Weidner JR, Wildey MJ, Wilson K, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004–. PMID: 36921077 Free Books & Documents. Review.
Small molecules to regulate the GH/IGF1 axis by inhibiting the growth hormone receptor synthesis.
van der Velden LM, Maas P, van Amersfoort M, Timmermans-Sprang EPM, Mensinga A, van der Vaart E, Malergue F, Viëtor H, Derksen PWB, Klumperman J, van Agthoven A, Egan DA, Mol JA, Strous GJ. van der Velden LM, et al. Among authors: egan da. Front Endocrinol (Lausanne). 2022 Jul 28;13:926210. doi: 10.3389/fendo.2022.926210. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35966052 Free PMC article.
High-Throughput Screening Identifies Idasanutlin as a Resensitizing Drug for Venetoclax-Resistant Neuroblastoma Cells.
Vernooij L, Bate-Eya LT, Alles LK, Lee JY, Koopmans B, Jonus HC, Schubert NA, Schild L, Lelieveld D, Egan DA, Kerstjens M, Stam RW, Koster J, Goldsmith KC, Molenaar JJ, Dolman MEM. Vernooij L, et al. Among authors: egan da. Mol Cancer Ther. 2021 Jun;20(6):1161-1172. doi: 10.1158/1535-7163.MCT-20-0666. Epub 2021 Apr 13. Mol Cancer Ther. 2021. PMID: 33850004 Free PMC article.
Combining Supervised and Unsupervised Machine Learning Methods for Phenotypic Functional Genomics Screening.
Omta WA, van Heesbeen RG, Shen I, de Nobel J, Robers D, van der Velden LM, Medema RH, Siebes APJM, Feelders AJ, Brinkkemper S, Klumperman JS, Spruit MR, Brinkhuis MJS, Egan DA. Omta WA, et al. Among authors: egan da. SLAS Discov. 2020 Jul;25(6):655-664. doi: 10.1177/2472555220919345. Epub 2020 May 13. SLAS Discov. 2020. PMID: 32400262 Free article.
CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches.
Argiriadi MA, Benatuil L, Dubrovska I, Egan DA, Gao L, Greischar A, Hardman J, Harlan J, Iyer RB, Judge RA, Lake M, Perron DC, Sadhukhan R, Sielaff B, Sousa S, Wang R, McRae BL. Argiriadi MA, et al. Among authors: egan da. BMC Mol Cell Biol. 2019 Aug 5;20(1):29. doi: 10.1186/s12860-019-0213-4. BMC Mol Cell Biol. 2019. PMID: 31382872 Free PMC article.
Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design.
Hobson AD, Judge RA, Aguirre AL, Brown BS, Cui Y, Ding P, Dominguez E, DiGiammarino E, Egan DA, Freiberg GM, Gopalakrishnan SM, Harris CM, Honore MP, Kage KL, Kapecki NJ, Ling C, Ma J, Mack H, Mamo M, Maurus S, McRae B, Moore NS, Mueller BK, Mueller R, Namovic MT, Patel K, Pratt SD, Putman CB, Queeney KL, Sarris KK, Schaffter LM, Stoll V, Vasudevan A, Wang L, Wang L, Wirthl W, Yach K. Hobson AD, et al. Among authors: egan da. J Med Chem. 2018 Dec 27;61(24):11074-11100. doi: 10.1021/acs.jmedchem.8b01098. Epub 2018 Dec 12. J Med Chem. 2018. PMID: 30384606
Intra-tumour diversification in colorectal cancer at the single-cell level.
Roerink SF, Sasaki N, Lee-Six H, Young MD, Alexandrov LB, Behjati S, Mitchell TJ, Grossmann S, Lightfoot H, Egan DA, Pronk A, Smakman N, van Gorp J, Anderson E, Gamble SJ, Alder C, van de Wetering M, Campbell PJ, Stratton MR, Clevers H. Roerink SF, et al. Among authors: egan da. Nature. 2018 Apr;556(7702):457-462. doi: 10.1038/s41586-018-0024-3. Epub 2018 Apr 11. Nature. 2018. PMID: 29643510
TMEM59 potentiates Wnt signaling by promoting signalosome formation.
Gerlach JP, Jordens I, Tauriello DVF, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJR, Egan DA, Maurice MM. Gerlach JP, et al. Among authors: egan da. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3996-E4005. doi: 10.1073/pnas.1721321115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632210 Free PMC article.
104 results