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Seed amplification and neurodegeneration marker trajectories in individuals at risk of prion disease.
Mok TH, Nihat A, Majbour N, Sequeira D, Holm-Mercer L, Coysh T, Darwent L, Batchelor M, Groveman BR, Orr CD, Hughson AG, Heslegrave A, Laban R, Veleva E, Paterson RW, Keshavan A, Schott JM, Swift IJ, Heller C, Rohrer JD, Gerhard A, Butler C, Rowe JB, Masellis M, Chapman M, Lunn MP, Bieschke J, Jackson GS, Zetterberg H, Caughey B, Rudge P, Collinge J, Mead S. Mok TH, et al. Among authors: bieschke j. Brain. 2023 Jun 1;146(6):2570-2583. doi: 10.1093/brain/awad101. Brain. 2023. PMID: 36975162 Free PMC article.
VCP suppresses proteopathic seeding in neurons.
Zhu J, Pittman S, Dhavale D, French R, Patterson JN, Kaleelurrrahuman MS, Sun Y, Vaquer-Alicea J, Maggiore G, Clemen CS, Buscher WJ, Bieschke J, Kotzbauer P, Ayala Y, Diamond MI, Davis AA, Weihl C. Zhu J, et al. Among authors: bieschke j. Mol Neurodegener. 2022 Apr 12;17(1):30. doi: 10.1186/s13024-022-00532-0. Mol Neurodegener. 2022. PMID: 35414105 Free PMC article.
Brazilin Removes Toxic Alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium.
Nahass GR, Sun Y, Xu Y, Batchelor M, Reilly M, Benilova I, Kedia N, Spehar K, Sobott F, Sessions RB, Caughey B, Radford SE, Jat PS, Collinge J, Bieschke J. Nahass GR, et al. Among authors: bieschke j. J Mol Biol. 2021 Apr 16;433(8):166878. doi: 10.1016/j.jmb.2021.166878. Epub 2021 Feb 19. J Mol Biol. 2021. PMID: 33610557 Free PMC article.
Structural effects of the highly protective V127 polymorphism on human prion protein.
Hosszu LLP, Conners R, Sangar D, Batchelor M, Sawyer EB, Fisher S, Cliff MJ, Hounslow AM, McAuley K, Leo Brady R, Jackson GS, Bieschke J, Waltho JP, Collinge J. Hosszu LLP, et al. Among authors: bieschke j. Commun Biol. 2020 Jul 29;3(1):402. doi: 10.1038/s42003-020-01126-6. Commun Biol. 2020. PMID: 32728168 Free PMC article.
47 results