Klompe SE - Search Results

1

Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases.

Lampe GD, King RT, Halpin-Healy TS, Klompe SE, Hogan MI, Vo PLH, Tang S, Chavez A, Sternberg SH. Lampe GD, et al. Among authors: klompe se. Nat Biotechnol. 2024 Jan;42(1):87-98. doi: 10.1038/s41587-023-01748-1. Epub 2023 Mar 29. Nat Biotechnol. 2024. PMID: 36991112 Free PMC article.

2

Harnessing "A Billion Years of Experimentation": The Ongoing Exploration and Exploitation of CRISPR-Cas Immune Systems.

Klompe SE, Sternberg SH. Klompe SE, et al. CRISPR J. 2018 Apr;1(2):141-158. doi: 10.1089/crispr.2018.0012. CRISPR J. 2018. PMID: 31021200 Free PMC article. Review.

3

Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration.

Klompe SE, Vo PLH, Halpin-Healy TS, Sternberg SH. Klompe SE, et al. Nature. 2019 Jul;571(7764):219-225. doi: 10.1038/s41586-019-1323-z. Epub 2019 Jun 12. Nature. 2019. PMID: 31189177

4

Harnessing type I CRISPR-Cas systems for genome engineering in human cells.

Cameron P, Coons MM, Klompe SE, Lied AM, Smith SC, Vidal B, Donohoue PD, Rotstein T, Kohrs BW, Nyer DB, Kennedy R, Banh LM, Williams C, Toh MS, Irby MJ, Edwards LS, Lin CH, Owen ALG, Künne T, van der Oost J, Brouns SJJ, Slorach EM, Fuller CK, Gradia S, Kanner SB, May AP, Sternberg SH. Cameron P, et al. Among authors: klompe se. Nat Biotechnol. 2019 Dec;37(12):1471-1477. doi: 10.1038/s41587-019-0310-0. Epub 2019 Nov 18. Nat Biotechnol. 2019. PMID: 31740839

5

Structural basis of DNA targeting by a transposon-encoded CRISPR-Cas system.

Halpin-Healy TS, Klompe SE, Sternberg SH, Fernández IS. Halpin-Healy TS, et al. Among authors: klompe se. Nature. 2020 Jan;577(7789):271-274. doi: 10.1038/s41586-019-1849-0. Epub 2019 Dec 18. Nature. 2020. PMID: 31853065

6

Publisher Correction: Structural basis of DNA targeting by a transposon-encoded CRISPR-Cas system.

Halpin-Healy TS, Klompe SE, Sternberg SH, Fernández IS. Halpin-Healy TS, et al. Among authors: klompe se. Nature. 2020 Sep;585(7825):E12. doi: 10.1038/s41586-020-2662-5. Nature. 2020. PMID: 32843756

7

CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering.

Vo PLH, Ronda C, Klompe SE, Chen EE, Acree C, Wang HH, Sternberg SH. Vo PLH, et al. Among authors: klompe se. Nat Biotechnol. 2021 Apr;39(4):480-489. doi: 10.1038/s41587-020-00745-y. Epub 2020 Nov 23. Nat Biotechnol. 2021. PMID: 33230293 Free PMC article.

8

Evolutionary and mechanistic diversity of Type I-F CRISPR-associated transposons.

Klompe SE, Jaber N, Beh LY, Mohabir JT, Bernheim A, Sternberg SH. Klompe SE, et al. Mol Cell. 2022 Feb 3;82(3):616-628.e5. doi: 10.1016/j.molcel.2021.12.021. Epub 2022 Jan 19. Mol Cell. 2022. PMID: 35051352 Free PMC article.

9

Novel molecular requirements for CRISPR RNA-guided transposition.

Walker MWG, Klompe SE, Zhang DJ, Sternberg SH. Walker MWG, et al. Among authors: klompe se. Nucleic Acids Res. 2023 May 22;51(9):4519-4535. doi: 10.1093/nar/gkad270. Nucleic Acids Res. 2023. PMID: 37078593 Free PMC article.

10

Bacterial genome engineering using CRISPR-associated transposases.

Gelsinger DR, Vo PLH, Klompe SE, Ronda C, Wang HH, Sternberg SH. Gelsinger DR, et al. Among authors: klompe se. Nat Protoc. 2024 Mar;19(3):752-790. doi: 10.1038/s41596-023-00927-3. Epub 2024 Jan 12. Nat Protoc. 2024. PMID: 38216671 Review.

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