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Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Mukadam AS, Miller LVC, Smith AE, Vaysburd M, Sakya SA, Sanford S, Keeling S, Tuck BJ, Katsinelos T, Green C, Skov L, Kaalund SS, Foss S, Mayes K, O'Connell K, Wing M, Knox C, Banbury J, Avezov E, Rowe JB, Goedert M, Andersen JT, James LC, McEwan WA. Mukadam AS, et al. Among authors: james lc. Science. 2023 Mar 31;379(6639):1336-1341. doi: 10.1126/science.abn1366. Epub 2023 Mar 30. Science. 2023. PMID: 36996217 Free PMC article.
Diverse HIV viruses are targeted by a conformationally dynamic antiviral.
Caines ME, Bichel K, Price AJ, McEwan WA, Towers GJ, Willett BJ, Freund SM, James LC. Caines ME, et al. Among authors: james lc. Nat Struct Mol Biol. 2012 Mar 11;19(4):411-6. doi: 10.1038/nsmb.2253. Nat Struct Mol Biol. 2012. PMID: 22407016 Free PMC article.
AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization.
Hauler F, Mallery DL, McEwan WA, Bidgood SR, James LC. Hauler F, et al. Among authors: james lc. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19733-8. doi: 10.1073/pnas.1210659109. Epub 2012 Oct 22. Proc Natl Acad Sci U S A. 2012. PMID: 23091005 Free PMC article.
Intracellular antibody receptor TRIM21 prevents fatal viral infection.
Vaysburd M, Watkinson RE, Cooper H, Reed M, O'Connell K, Smith J, Cruickshanks J, James LC. Vaysburd M, et al. Among authors: james lc. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12397-401. doi: 10.1073/pnas.1301918110. Epub 2013 Jul 9. Proc Natl Acad Sci U S A. 2013. PMID: 23840060 Free PMC article.
Intracellular antibody immunity.
Watkinson RE, McEwan WA, James LC. Watkinson RE, et al. Among authors: james lc. J Clin Immunol. 2014 Jul;34 Suppl 1:S30-4. doi: 10.1007/s10875-014-0017-4. Epub 2014 Apr 11. J Clin Immunol. 2014. PMID: 24722852 Review.
149 results