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Preclinical discovery and initial clinical data of WVT078, a BCMA × CD3 bispecific antibody.
Raab MS, Cohen YC, Schjesvold F, Aardalen K, Oka A, Spencer A, Wermke M, Souza AD, Kaufman JL, Cafro AM, Ocio EM, Doki N, Henson K, Trabucco G, Carrion A, Bender FC, Juif PE, Fessehatsion A, Fan L, Stonehouse JP, Blankenship JW, Granda B, De Vita S, Lu H. Raab MS, et al. Among authors: blankenship jw. Leukemia. 2023 Jun;37(6):1349-1360. doi: 10.1038/s41375-023-01883-3. Epub 2023 Apr 6. Leukemia. 2023. PMID: 37024520
Clearance of plasma PCSK9 via the asialoglycoprotein receptor mediated by heterobifunctional ligands.
Bagdanoff JT, Smith TM, Allan M, O'Donnell P, Nguyen Z, Moore EA, Baird J, Wang S, Subramanian V, Tigani B, Nettleton DO, Monovich LG, Lewis I, Flyer AN, Granda B, Blankenship JW, Barnes-Seeman D, Clairmont KB. Bagdanoff JT, et al. Among authors: blankenship jw. Cell Chem Biol. 2023 Jan 19;30(1):97-109.e9. doi: 10.1016/j.chembiol.2022.12.003. Epub 2023 Jan 9. Cell Chem Biol. 2023. PMID: 36626903 Free article.
MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer.
Hernandez-Hoyos G, Sewell T, Bader R, Bannink J, Chenault RA, Daugherty M, Dasovich M, Fang H, Gottschalk R, Kumer J, Miller RE, Ravikumar P, Wiens J, Algate PA, Bienvenue D, McMahan CJ, Natarajan SK, Gross JA, Blankenship JW. Hernandez-Hoyos G, et al. Among authors: blankenship jw. Mol Cancer Ther. 2016 Sep;15(9):2155-65. doi: 10.1158/1535-7163.MCT-15-0242. Epub 2016 Jul 12. Mol Cancer Ther. 2016. PMID: 27406985
Internal motions prime cIAP1 for rapid activation.
Phillips AH, Schoeffler AJ, Matsui T, Weiss TM, Blankenship JW, Zobel K, Giannetti AM, Dueber EC, Fairbrother WJ. Phillips AH, et al. Among authors: blankenship jw. Nat Struct Mol Biol. 2014 Dec;21(12):1068-74. doi: 10.1038/nsmb.2916. Epub 2014 Nov 10. Nat Struct Mol Biol. 2014. PMID: 25383668
Thermodynamics of a designed protein catenane.
Blankenship JW, Dawson PE. Blankenship JW, et al. J Mol Biol. 2003 Mar 21;327(2):537-48. doi: 10.1016/s0022-2836(03)00115-3. J Mol Biol. 2003. PMID: 12628256
31 results