Knollmann BC - Search Results

1

Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy.

Marchiano S, Nakamura K, Reinecke H, Neidig L, Lai M, Kadota S, Perbellini F, Yang X, Klaiman JM, Blakely LP, Karbassi E, Fields PA, Fenix AM, Beussman KM, Jayabalu A, Kalucki FA, Potter JC, Futakuchi-Tsuchida A, Weber GJ, Dupras S, Tsuchida H, Pabon L, Wang L, Knollmann BC, Kattman S, Thies RS, Sniadecki N, MacLellan WR, Bertero A, Murry CE. Marchiano S, et al. Among authors: knollmann bc. Cell Stem Cell. 2023 Apr 6;30(4):396-414.e9. doi: 10.1016/j.stem.2023.03.010. Cell Stem Cell. 2023. PMID: 37028405 Free PMC article.

2

Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy.

Sequeira V, Wang L, Wijnker PJM, Kim K, Pinto JR, Dos Remedios C, Redwood C, Knollmann BC, van der Velden J. Sequeira V, et al. Among authors: knollmann bc. J Mol Cell Cardiol Plus. 2022 Sep;1:100007. doi: 10.1016/j.jmccpl.2022.100007. J Mol Cell Cardiol Plus. 2022. PMID: 37159677 Free PMC article.

3

Real-Time Measurements of Calcium and Contractility Parameters in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Dinani R, Manders E, Helmes M, Wang L, Knollmann B, Kuster DWD, van der Velden J. Dinani R, et al. J Vis Exp. 2023 May 26;(195). doi: 10.3791/65326. J Vis Exp. 2023. PMID: 37306462

4

Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium-glucose cotransporter 2 inhibitors.

Wijnker PJM, Dinani R, van der Laan NC, Algül S, Knollmann BC, Verkerk AO, Remme CA, Zuurbier CJ, Kuster DWD, van der Velden J. Wijnker PJM, et al. Among authors: knollmann bc. Cardiovasc Res. 2024 Mar 14;120(3):301-317. doi: 10.1093/cvr/cvae004. Cardiovasc Res. 2024. PMID: 38240646 Free PMC article.

5

Genetic Inhibition of Mitochondrial Permeability Transition Pore Exacerbates Ryanodine Receptor 2 Dysfunction in Arrhythmic Disease.

Deb A, Tow BD, Qing Y, Walker M, Hodges ER, Stewart JA Jr, Knollmann BC, Zheng Y, Wang Y, Liu B. Deb A, et al. Among authors: knollmann bc. Cells. 2023 Jan 4;12(2):204. doi: 10.3390/cells12020204. Cells. 2023. PMID: 36672139 Free PMC article.

6

The selective RyR2 inhibitor ent-verticilide suppresses atrial fibrillation susceptibility caused by Pitx2 deficiency.

Kim K, Blackwell DJ, Yuen SL, Thorpe MP, Johnston JN, Cornea RL, Knollmann BC. Kim K, et al. Among authors: knollmann bc. J Mol Cell Cardiol. 2023 Jul;180:1-9. doi: 10.1016/j.yjmcc.2023.04.005. Epub 2023 Apr 18. J Mol Cell Cardiol. 2023. PMID: 37080450

7

RyR2 inhibition with dantrolene is antiarrhythmic, prevents further pathological remodeling, and improves cardiac function in chronic ischemic heart disease.

Schmeckpeper J, Kim K, George SA, Blackwell DJ, Brennan JA, Efimov IR, Knollmann BC. Schmeckpeper J, et al. Among authors: knollmann bc. J Mol Cell Cardiol. 2023 Aug;181:67-78. doi: 10.1016/j.yjmcc.2023.05.009. Epub 2023 Jun 5. J Mol Cell Cardiol. 2023. PMID: 37285929

8

Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function, and prevents sudden arrhythmic death in failing hearts.

Joshi P, Estes S, DeMazumder D, Knollmann BC, Dey S. Joshi P, et al. Among authors: knollmann bc. Elife. 2023 Dec 11;12:RP88638. doi: 10.7554/eLife.88638. Elife. 2023. PMID: 38078905 Free PMC article. Clinical Trial.

9

Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2.

Rodriguez Garcia M, Schmeckpeper J, Landim-Vieira M, Coscarella IL, Fang X, Ma W, Spran PA, Yuan S, Qi L, Kahmini AR, Shoemaker MB, Atkinson JB, Kekenes-Huskey PM, Irving TC, Chase PB, Knollmann BC, Pinto JR. Rodriguez Garcia M, et al. Among authors: knollmann bc. Int J Mol Sci. 2023 Sep 26;24(19):14572. doi: 10.3390/ijms241914572. Int J Mol Sci. 2023. PMID: 37834023 Free PMC article.

10

The proteostasis interactomes of trafficking-deficient K _V 11.1 variants associated with Long QT Syndrome and pharmacological chaperone rescue.

Egly CL, Barny L, Do T, McDonald EF, Plate L, Knollmann BC. Egly CL, et al. Among authors: knollmann bc. bioRxiv [Preprint]. 2024 Jan 31:2024.01.31.574410. doi: 10.1101/2024.01.31.574410. bioRxiv. 2024. PMID: 38352392 Free PMC article. Preprint.

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