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Counteracting lineage-specific transcription factor network finely tunes lung adeno-to-squamous transdifferentiation through remodeling tumor immune microenvironment.
Tang S, Xue Y, Qin Z, Fang Z, Sun Y, Yuan C, Pan Y, Zhao Y, Tong X, Zhang J, Huang H, Chen Y, Hu L, Huang D, Wang R, Zou W, Li Y, Thomas RK, Ventura A, Wong KK, Chen H, Chen L, Ji H. Tang S, et al. Among authors: huang d, huang h. Natl Sci Rev. 2023 Feb 14;10(4):nwad028. doi: 10.1093/nsr/nwad028. eCollection 2023 Apr. Natl Sci Rev. 2023. PMID: 37051524 Free PMC article.
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis.
Wu Q, Tian Y, Zhang J, Tong X, Huang H, Li S, Zhao H, Tang Y, Yuan C, Wang K, Fang Z, Gao L, Hu X, Li F, Qin Z, Yao S, Chen T, Chen H, Zhang G, Liu W, Sun Y, Chen L, Wong KK, Ge K, Chen L, Ji H. Wu Q, et al. Among authors: huang h. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3978-E3986. doi: 10.1073/pnas.1716589115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632194 Free PMC article.
Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin β1.
Zhao G, Gong L, Su D, Jin Y, Guo C, Yue M, Yao S, Qin Z, Ye Y, Tang Y, Wu Q, Zhang J, Cui B, Ding Q, Huang H, Hu L, Chen Y, Zhang P, Hu G, Chen L, Wong KK, Gao D, Ji H. Zhao G, et al. Among authors: huang h. J Clin Invest. 2019 Mar 1;129(3):972-987. doi: 10.1172/JCI122779. Epub 2019 Jan 28. J Clin Invest. 2019. PMID: 30688657 Free PMC article.
Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition.
Gao L, Hu Y, Tian Y, Fan Z, Wang K, Li H, Zhou Q, Zeng G, Hu X, Yu L, Zhou S, Tong X, Huang H, Chen H, Liu Q, Liu W, Zhang G, Zeng M, Zhou G, He Q, Ji H, Chen L. Gao L, et al. Among authors: huang h. Nat Commun. 2019 Apr 10;10(1):1665. doi: 10.1038/s41467-019-09295-7. Nat Commun. 2019. PMID: 30971692 Free PMC article.
Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors.
Wang Y, Zhang J, Ren S, Sun D, Huang HY, Wang H, Jin Y, Li F, Zheng C, Yang L, Deng L, Jiang Z, Jiang T, Han X, Hou S, Guo C, Li F, Gao D, Qin J, Gao D, Chen L, Lin SH, Wong KK, Li C, Hu L, Zhou C, Ji H. Wang Y, et al. Among authors: huang hy. Cell Rep. 2019 Jul 9;28(2):512-525.e6. doi: 10.1016/j.celrep.2019.06.026. Cell Rep. 2019. PMID: 31291585 Free article.
Specific gut microbiome signature predicts the early-stage lung cancer.
Zheng Y, Fang Z, Xue Y, Zhang J, Zhu J, Gao R, Yao S, Ye Y, Wang S, Lin C, Chen S, Huang H, Hu L, Jiang GN, Qin H, Zhang P, Chen J, Ji H. Zheng Y, et al. Among authors: huang h. Gut Microbes. 2020 Jul 3;11(4):1030-1042. doi: 10.1080/19490976.2020.1737487. Epub 2020 Apr 2. Gut Microbes. 2020. PMID: 32240032 Free PMC article.
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