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The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.
Cox TR, Rumney RMH, Schoof EM, Perryman L, Høye AM, Agrawal A, Bird D, Latif NA, Forrest H, Evans HR, Huggins ID, Lang G, Linding R, Gartland A, Erler JT. Cox TR, et al. Among authors: huggins id. Nature. 2015 Jun 4;522(7554):106-110. doi: 10.1038/nature14492. Epub 2015 May 27. Nature. 2015. PMID: 26017313 Free PMC article. Retracted.
Osteolytica: An automated image analysis software package that rapidly measures cancer-induced osteolytic lesions in in vivo models with greater reproducibility compared to other commonly used methods.
Evans HR, Karmakharm T, Lawson MA, Walker RE, Harris W, Fellows C, Huggins ID, Richmond P, Chantry AD. Evans HR, et al. Among authors: huggins id. Bone. 2016 Feb;83:9-16. doi: 10.1016/j.bone.2015.10.004. Epub 2015 Oct 8. Bone. 2016. PMID: 26456145 Free PMC article.