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Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration.
Laperle AH, Moser VA, Avalos P, Lu B, Wu A, Fulton A, Ramirez S, Garcia VJ, Bell S, Ho R, Lawless G, Roxas K, Shahin S, Shelest O, Svendsen S, Wang S, Svendsen CN. Laperle AH, et al. Among authors: avalos p. Stem Cell Reports. 2023 Aug 8;18(8):1629-1642. doi: 10.1016/j.stemcr.2023.03.016. Epub 2023 Apr 20. Stem Cell Reports. 2023. PMID: 37084724 Free PMC article.
Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats.
Gowing G, Shelley B, Staggenborg K, Hurley A, Avalos P, Victoroff J, Latter J, Garcia L, Svendsen CN. Gowing G, et al. Among authors: avalos p. Neuroreport. 2014 Apr 16;25(6):367-72. doi: 10.1097/WNR.0000000000000092. Neuroreport. 2014. PMID: 24284956 Free PMC article.
Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex.
Thomsen GM, Gowing G, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK, Svendsen CN. Thomsen GM, et al. Among authors: avalos p. J Neurosci. 2014 Nov 19;34(47):15587-600. doi: 10.1523/JNEUROSCI.2037-14.2014. J Neurosci. 2014. PMID: 25411487 Free PMC article.
47 results