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Page 1
Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Lazear MR, Remsberg JR, Jaeger MG, Rothamel K, Her HL, DeMeester KE, Njomen E, Hogg SJ, Rahman J, Whitby LR, Won SJ, Schafroth MA, Ogasawara D, Yokoyama M, Lindsey GL, Li H, Germain J, Barbas S, Vaughan J, Hanigan TW, Vartabedian VF, Reinhardt CJ, Dix MM, Koo SJ, Heo I, Teijaro JR, Simon GM, Ghosh B, Abdel-Wahab O, Ahn K, Saghatelian A, Melillo B, Schreiber SL, Yeo GW, Cravatt BF. Lazear MR, et al. Among authors: schafroth ma. Mol Cell. 2023 May 18;83(10):1725-1742.e12. doi: 10.1016/j.molcel.2023.03.026. Epub 2023 Apr 20. Mol Cell. 2023. PMID: 37084731 Free PMC article.
Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension.
Rinschen MM, Palygin O, El-Meanawy A, Domingo-Almenara X, Palermo A, Dissanayake LV, Golosova D, Schafroth MA, Guijas C, Demir F, Jaegers J, Gliozzi ML, Xue J, Hoehne M, Benzing T, Kok BP, Saez E, Bleich M, Himmerkus N, Weisz OA, Cravatt BF, Krüger M, Benton HP, Siuzdak G, Staruschenko A. Rinschen MM, et al. Among authors: schafroth ma. Nat Commun. 2022 Jul 14;13(1):4099. doi: 10.1038/s41467-022-31670-0. Nat Commun. 2022. PMID: 35835746 Free PMC article.
In situ identification of cellular drug targets in mammalian tissue.
Pang Z, Schafroth MA, Ogasawara D, Wang Y, Nudell V, Lal NK, Yang D, Wang K, Herbst DM, Ha J, Guijas C, Blankman JL, Cravatt BF, Ye L. Pang Z, et al. Among authors: schafroth ma. Cell. 2022 May 12;185(10):1793-1805.e17. doi: 10.1016/j.cell.2022.03.040. Epub 2022 Apr 27. Cell. 2022. PMID: 35483372 Free PMC article.
Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold.
Rong J, Mori W, Xia X, Schafroth MA, Zhao C, Van RS, Yamasaki T, Chen J, Xiao Z, Haider A, Ogasawara D, Hiraishi A, Shao T, Zhang Y, Chen Z, Pang F, Hu K, Xie L, Fujinaga M, Kumata K, Gou Y, Fang Y, Gu S, Wei H, Bao L, Xu H, Collier TL, Shao Y, Carson RE, Cravatt BF, Wang L, Zhang MR, Liang SH. Rong J, et al. Among authors: schafroth ma. J Med Chem. 2021 Oct 14;64(19):14283-14298. doi: 10.1021/acs.jmedchem.1c00747. Epub 2021 Sep 27. J Med Chem. 2021. PMID: 34569803 Free PMC article.
Δ9-cis-Tetrahydrocannabinol: Natural Occurrence, Chirality, and Pharmacology.
Schafroth MA, Mazzoccanti G, Reynoso-Moreno I, Erni R, Pollastro F, Caprioglio D, Botta B, Allegrone G, Grassi G, Chicca A, Gasparrini F, Gertsch J, Carreira EM, Appendino G. Schafroth MA, et al. J Nat Prod. 2021 Sep 24;84(9):2502-2510. doi: 10.1021/acs.jnatprod.1c00513. Epub 2021 Jul 25. J Nat Prod. 2021. PMID: 34304557 Free article.
Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping.
Chen Z, Mori W, Rong J, Schafroth MA, Shao T, Van RS, Ogasawara D, Yamasaki T, Hiraishi A, Hatori A, Chen J, Zhang Y, Hu K, Fujinaga M, Sun J, Yu Q, Collier TL, Shao Y, Cravatt BF, Josephson L, Zhang MR, Liang SH. Chen Z, et al. Among authors: schafroth ma. Acta Pharm Sin B. 2021 Jun;11(6):1686-1695. doi: 10.1016/j.apsb.2021.01.021. Epub 2021 Apr 1. Acta Pharm Sin B. 2021. PMID: 34221877 Free PMC article.
DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras.
Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, Kikuchi S, Weinstein DS, Symons KT, Nordin BE, Rodriguez JL, Wucherpfennig TG, Bauer LG, Dix MM, Stamos D, Kinsella TM, Simon GM, Baltgalvis KA, Cravatt BF. Zhang X, et al. Among authors: schafroth ma. J Am Chem Soc. 2021 Apr 7;143(13):5141-5149. doi: 10.1021/jacs.1c00990. Epub 2021 Mar 30. J Am Chem Soc. 2021. PMID: 33783207 Free PMC article.
Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development.
Hou L, Rong J, Haider A, Ogasawara D, Varlow C, Schafroth MA, Mu L, Gan J, Xu H, Fowler CJ, Zhang MR, Vasdev N, Ametamey S, Cravatt BF, Wang L, Liang SH. Hou L, et al. Among authors: schafroth ma. J Med Chem. 2021 Jan 14;64(1):123-149. doi: 10.1021/acs.jmedchem.0c01459. Epub 2020 Dec 30. J Med Chem. 2021. PMID: 33379862 Free PMC article. Review.
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, Lazear MR, Yin S, Blewett MM, Dix MM, Nguyen N, Shokhirev MN, Chin EN, Lairson LL, Melillo B, Schreiber SL, Forli S, Teijaro JR, Cravatt BF. Vinogradova EV, et al. Among authors: schafroth ma. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29. Cell. 2020. PMID: 32730809 Free PMC article.
22 results