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Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression.
Jana S, Brahma S, Arora S, Wladyka CL, Hoang P, Blinka S, Hough R, Horn JL, Liu Y, Wang LJ, Depeille P, Smith E, Montgomery RB, Lee JK, Haffner MC, Vakar-Lopez F, Grivas P, Wright JL, Lam HM, Black PC, Roose JP, Ryazanov AG, Subramaniam AR, Henikoff S, Hsieh AC. Jana S, et al. Among authors: wladyka cl. Cancer Cell. 2023 May 8;41(5):853-870.e13. doi: 10.1016/j.ccell.2023.03.021. Epub 2023 Apr 20. Cancer Cell. 2023. PMID: 37084735 Free PMC article.
Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases.
Kartha N, Gianopulos JE, Schrank Z, Cavender SM, Dobersch S, Kynnap BD, Wallace-Povirk A, Wladyka CL, Santana JF, Kim JC, Yu A, Bridgwater CM, Fuchs K, Dysinger S, Lampano AE, Notta F, Price DH, Hsieh AC, Hingorani SR, Kugel S. Kartha N, et al. Among authors: wladyka cl. Sci Transl Med. 2023 May 3;15(694):eabn9674. doi: 10.1126/scitranslmed.abn9674. Epub 2023 May 3. Sci Transl Med. 2023. PMID: 37134154 Free PMC article.
The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs.
Hamm DC, Paatela EM, Bennett SR, Wong CJ, Campbell AE, Wladyka CL, Smith AA, Jagannathan S, Hsieh AC, Tapscott SJ. Hamm DC, et al. Among authors: wladyka cl. PLoS Biol. 2023 Sep 25;21(9):e3002317. doi: 10.1371/journal.pbio.3002317. eCollection 2023 Sep. PLoS Biol. 2023. PMID: 37747887 Free PMC article.
Pbx3 is required for normal locomotion and dorsal horn development.
Rottkamp CA, Lobur KJ, Wladyka CL, Lucky AK, O'Gorman S. Rottkamp CA, et al. Among authors: wladyka cl. Dev Biol. 2008 Feb 1;314(1):23-39. doi: 10.1016/j.ydbio.2007.10.046. Epub 2007 Nov 12. Dev Biol. 2008. PMID: 18155191 Free article.