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Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression.
Cancer Cell. 2023 May 8;41(5):853-870.e13. doi: 10.1016/j.ccell.2023.03.021. Epub 2023 Apr 20.
Cancer Cell. 2023.
PMID: 37084735
Free PMC article.
Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases.
Kartha N, Gianopulos JE, Schrank Z, Cavender SM, Dobersch S, Kynnap BD, Wallace-Povirk A, Wladyka CL, Santana JF, Kim JC, Yu A, Bridgwater CM, Fuchs K, Dysinger S, Lampano AE, Notta F, Price DH, Hsieh AC, Hingorani SR, Kugel S.
Kartha N, et al. Among authors: wladyka cl.
Sci Transl Med. 2023 May 3;15(694):eabn9674. doi: 10.1126/scitranslmed.abn9674. Epub 2023 May 3.
Sci Transl Med. 2023.
PMID: 37134154
Free PMC article.
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Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3' untranslated region mutations.
Schuster SL, Arora S, Wladyka CL, Itagi P, Corey L, Young D, Stackhouse BL, Kollath L, Wu QV, Corey E, True LD, Ha G, Paddison PJ, Hsieh AC.
Schuster SL, et al. Among authors: wladyka cl.
Cell Rep. 2023 Aug 29;42(8):112840. doi: 10.1016/j.celrep.2023.112840. Epub 2023 Jul 28.
Cell Rep. 2023.
PMID: 37516102
Free PMC article.
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The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs.
Hamm DC, Paatela EM, Bennett SR, Wong CJ, Campbell AE, Wladyka CL, Smith AA, Jagannathan S, Hsieh AC, Tapscott SJ.
Hamm DC, et al. Among authors: wladyka cl.
PLoS Biol. 2023 Sep 25;21(9):e3002317. doi: 10.1371/journal.pbio.3002317. eCollection 2023 Sep.
PLoS Biol. 2023.
PMID: 37747887
Free PMC article.
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Multiplexed functional genomic analysis of 5' untranslated region mutations across the spectrum of prostate cancer.
Lim Y, Arora S, Schuster SL, Corey L, Fitzgibbon M, Wladyka CL, Wu X, Coleman IM, Delrow JJ, Corey E, True LD, Nelson PS, Ha G, Hsieh AC.
Lim Y, et al. Among authors: wladyka cl.
Nat Commun. 2021 Jul 9;12(1):4217. doi: 10.1038/s41467-021-24445-6.
Nat Commun. 2021.
PMID: 34244513
Free PMC article.
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Pbx3 is required for normal locomotion and dorsal horn development.
Rottkamp CA, Lobur KJ, Wladyka CL, Lucky AK, O'Gorman S.
Rottkamp CA, et al. Among authors: wladyka cl.
Dev Biol. 2008 Feb 1;314(1):23-39. doi: 10.1016/j.ydbio.2007.10.046. Epub 2007 Nov 12.
Dev Biol. 2008.
PMID: 18155191
Free article.
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The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats.
Wladyka CL, Feng B, Glazebrook PA, Schild JH, Kunze DL.
Wladyka CL, et al.
J Physiol. 2008 Feb 1;586(3):795-802. doi: 10.1113/jphysiol.2007.145284. Epub 2007 Nov 29.
J Physiol. 2008.
PMID: 18048450
Free PMC article.
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KCNQ/M-currents contribute to the resting membrane potential in rat visceral sensory neurons.
Wladyka CL, Kunze DL.
Wladyka CL, et al.
J Physiol. 2006 Aug 15;575(Pt 1):175-89. doi: 10.1113/jphysiol.2006.113308. Epub 2006 Jun 15.
J Physiol. 2006.
PMID: 16777937
Free PMC article.
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