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Plasma membrane preassociation drives β-arrestin coupling to receptors and activation.
Grimes J, Koszegi Z, Lanoiselée Y, Miljus T, O'Brien SL, Stepniewski TM, Medel-Lacruz B, Baidya M, Makarova M, Mistry R, Goulding J, Drube J, Hoffmann C, Owen DM, Shukla AK, Selent J, Hill SJ, Calebiro D. Grimes J, et al. Among authors: selent j. Cell. 2023 May 11;186(10):2238-2255.e20. doi: 10.1016/j.cell.2023.04.018. Epub 2023 May 4. Cell. 2023. PMID: 37146613 Free PMC article.
Palmitoylation of cysteine 415 of CB1 receptor affects ligand-stimulated internalization and selective interaction with membrane cholesterol and caveolin 1.
Oddi S, Stepniewski TM, Totaro A, Selent J, Scipioni L, Dufrusine B, Fezza F, Dainese E, Maccarrone M. Oddi S, et al. Among authors: selent j. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May;1862(5):523-532. doi: 10.1016/j.bbalip.2017.02.004. Epub 2017 Feb 12. Biochim Biophys Acta Mol Cell Biol Lipids. 2017. PMID: 28215712
Challenges and Opportunities in Drug Discovery of Biased Ligands.
Rodríguez-Espigares I, Kaczor AA, Stepniewski TM, Selent J. Rodríguez-Espigares I, et al. Among authors: selent j. Methods Mol Biol. 2018;1705:321-334. doi: 10.1007/978-1-4939-7465-8_14. Methods Mol Biol. 2018. PMID: 29188569 Review.
Protein-Protein Docking in Drug Design and Discovery.
Kaczor AA, Bartuzi D, Stępniewski TM, Matosiuk D, Selent J. Kaczor AA, et al. Among authors: selent j. Methods Mol Biol. 2018;1762:285-305. doi: 10.1007/978-1-4939-7756-7_15. Methods Mol Biol. 2018. PMID: 29594778
Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms.
Ghosh E, Dwivedi H, Baidya M, Srivastava A, Kumari P, Stepniewski T, Kim HR, Lee MH, van Gastel J, Chaturvedi M, Roy D, Pandey S, Maharana J, Guixà-González R, Luttrell LM, Chung KY, Dutta S, Selent J, Shukla AK. Ghosh E, et al. Among authors: selent j. Cell Rep. 2019 Sep 24;28(13):3287-3299.e6. doi: 10.1016/j.celrep.2019.08.053. Cell Rep. 2019. PMID: 31553900 Free PMC article.
GPCRmd uncovers the dynamics of the 3D-GPCRome.
Rodríguez-Espigares I, Torrens-Fontanals M, Tiemann JKS, Aranda-García D, Ramírez-Anguita JM, Stepniewski TM, Worp N, Varela-Rial A, Morales-Pastor A, Medel-Lacruz B, Pándy-Szekeres G, Mayol E, Giorgino T, Carlsson J, Deupi X, Filipek S, Filizola M, Gómez-Tamayo JC, Gonzalez A, Gutiérrez-de-Terán H, Jiménez-Rosés M, Jespers W, Kapla J, Khelashvili G, Kolb P, Latek D, Marti-Solano M, Matricon P, Matsoukas MT, Miszta P, Olivella M, Perez-Benito L, Provasi D, Ríos S, R Torrecillas I, Sallander J, Sztyler A, Vasile S, Weinstein H, Zachariae U, Hildebrand PW, De Fabritiis G, Sanz F, Gloriam DE, Cordomi A, Guixà-González R, Selent J. Rodríguez-Espigares I, et al. Among authors: selent j. Nat Methods. 2020 Aug;17(8):777-787. doi: 10.1038/s41592-020-0884-y. Epub 2020 Jul 13. Nat Methods. 2020. PMID: 32661425
82 results