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Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial.
Abel ML, Takahashi N, Peer C, Redon CE, Nichols S, Vilimas R, Lee MJ, Lee S, Shelat M, Kattappuram R, Sciuto L, Pinkiert D, Graham C, Butcher D, Karim B, Sharma AK, Malin J, Kumar R, Schultz CW, Goyal S, Del Rivero J, Krishnamurthy M, Upadhyay D, Schroeder B, Sissung T, Tyagi M, Kim J, Pommier Y, Aladjem M, Raffeld M, Figg WD, Trepel J, Xi L, Desai P, Thomas A. Abel ML, et al. Among authors: karim b. Clin Cancer Res. 2023 Sep 15;29(18):3603-3611. doi: 10.1158/1078-0432.CCR-23-0536. Clin Cancer Res. 2023. PMID: 37227187 Free PMC article.
P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis.
Yamakuchi M, Lotterman CD, Bao C, Hruban RH, Karim B, Mendell JT, Huso D, Lowenstein CJ. Yamakuchi M, et al. Among authors: karim b. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6334-9. doi: 10.1073/pnas.0911082107. Epub 2010 Mar 22. Proc Natl Acad Sci U S A. 2010. PMID: 20308559 Free PMC article.
Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence.
Tomasetti C, Poling J, Roberts NJ, London NR Jr, Pittman ME, Haffner MC, Rizzo A, Baras A, Karim B, Kim A, Heaphy CM, Meeker AK, Hruban RH, Iacobuzio-Donahue CA, Vogelstein B. Tomasetti C, et al. Among authors: karim b. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20482-20488. doi: 10.1073/pnas.1905722116. Epub 2019 Sep 23. Proc Natl Acad Sci U S A. 2019. PMID: 31548407 Free PMC article.
123 results