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In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.
Dervovic D, Malik AA, Chen ELY, Narimatsu M, Adler N, Afiuni-Zadeh S, Krenbek D, Martinez S, Tsai R, Boucher J, Berman JM, Teng K, Ayyaz A, Lü Y, Mbamalu G, Loganathan SK, Lee J, Zhang L, Guidos C, Wrana J, Valipour A, Roux PP, Reimand J, Jackson HW, Schramek D. Dervovic D, et al. Among authors: roux pp. Nat Commun. 2023 May 31;14(1):3150. doi: 10.1038/s41467-023-38841-7. Nat Commun. 2023. PMID: 37258521 Free PMC article.
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.
Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, Meloche S, Angers S, Roux PP. Aubert L, et al. Among authors: roux pp. Nat Commun. 2020 Jul 24;11(1):3701. doi: 10.1038/s41467-020-17549-y. Nat Commun. 2020. PMID: 32709883 Free PMC article.
An ErbB2 splice variant lacking exon 16 drives lung carcinoma.
Smith HW, Yang L, Ling C, Walsh A, Martinez VD, Boucher J, Zuo D, Sokol ES, Pavlick DC, Frampton GM, Chmielecki J, Jones LM, Roux PP, Lockwood WW, Muller WJ. Smith HW, et al. Among authors: roux pp. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20139-20148. doi: 10.1073/pnas.2007474117. Epub 2020 Jul 29. Proc Natl Acad Sci U S A. 2020. PMID: 32727899 Free PMC article.
CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma.
Houles T, Lavoie G, Nourreddine S, Cheung W, Vaillancourt-Jean É, Guérin CM, Bouttier M, Grondin B, Lin S, Saba-El-Leil MK, Angers S, Meloche S, Roux PP. Houles T, et al. Among authors: roux pp. Nat Commun. 2022 Oct 29;13(1):6457. doi: 10.1038/s41467-022-34179-8. Nat Commun. 2022. PMID: 36309522 Free PMC article.
HER2Δ16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer.
Attalla SS, Boucher J, Proud H, Taifour T, Zuo D, Sanguin-Gendreau V, Ling C, Johnson G, Li V, Luo RB, Kuasne H, Papavasiliou V, Walsh LA, Barok M, Joensuu H, Park M, Roux PP, Muller WJ. Attalla SS, et al. Among authors: roux pp. Cancer Immunol Res. 2023 Sep 1;11(9):1184-1202. doi: 10.1158/2326-6066.CIR-22-0140. Cancer Immunol Res. 2023. PMID: 37311021
Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.
Dervovic D, Malik AA, Chen ELY, Narimatsu M, Adler N, Afiuni-Zadeh S, Krenbek D, Martinez S, Tsai R, Boucher J, Berman JM, Teng K, Ayyaz A, Lü Y, Mbamalu G, Loganathan SK, Lee J, Zhang L, Guidos C, Wrana J, Valipour A, Roux PP, Reimand J, Jackson HW, Schramek D. Dervovic D, et al. Among authors: roux pp. Nat Commun. 2023 Sep 5;14(1):5404. doi: 10.1038/s41467-023-41255-0. Nat Commun. 2023. PMID: 37670013 Free PMC article. No abstract available.
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling.
Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich FM, Khoury E, Audet M, Roux PP, Veprintsev DB, Laporte SA, Bouvier M. Beautrait A, et al. Among authors: roux pp. Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054. Nat Commun. 2017. PMID: 28416805 Free PMC article.
108 results