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Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.
Haston S, Gonzalez-Gualda E, Morsli S, Ge J, Reen V, Calderwood A, Moutsopoulos I, Panousopoulos L, Deletic P, Carreno G, Guiho R, Manshaei S, Gonzalez-Meljem JM, Lim HY, Simpson DJ, Birch J, Pallikonda HA, Chandra T, Macias D, Doherty GJ, Rassl DM, Rintoul RC, Signore M, Mohorianu I, Akbar AN, Gil J, Muñoz-Espín D, Martinez-Barbera JP. Haston S, et al. Among authors: carreno g. Cancer Cell. 2023 Jul 10;41(7):1242-1260.e6. doi: 10.1016/j.ccell.2023.05.004. Epub 2023 Jun 1. Cancer Cell. 2023. PMID: 37267953 Free article.
Stem cells and their role in pituitary tumorigenesis.
Carreno G, Gonzalez-Meljem JM, Haston S, Martinez-Barbera JP. Carreno G, et al. Mol Cell Endocrinol. 2017 Apr 15;445:27-34. doi: 10.1016/j.mce.2016.10.005. Epub 2016 Oct 6. Mol Cell Endocrinol. 2017. PMID: 27720895 Free article. Review.
Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.
Gonzalez-Meljem JM, Haston S, Carreno G, Apps JR, Pozzi S, Stache C, Kaushal G, Virasami A, Panousopoulos L, Mousavy-Gharavy SN, Guerrero A, Rashid M, Jani N, Goding CR, Jacques TS, Adams DJ, Gil J, Andoniadou CL, Martinez-Barbera JP. Gonzalez-Meljem JM, et al. Among authors: carreno g. Nat Commun. 2017 Nov 28;8(1):1819. doi: 10.1038/s41467-017-01992-5. Nat Commun. 2017. PMID: 29180744 Free PMC article.
MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.
Haston S, Pozzi S, Carreno G, Manshaei S, Panousopoulos L, Gonzalez-Meljem JM, Apps JR, Virasami A, Thavaraj S, Gutteridge A, Forshew T, Marais R, Brandner S, Jacques TS, Andoniadou CL, Martinez-Barbera JP. Haston S, et al. Among authors: carreno g. Development. 2017 Jun 15;144(12):2141-2152. doi: 10.1242/dev.150490. Epub 2017 May 15. Development. 2017. PMID: 28506993 Free PMC article.
Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target.
Apps JR, Carreno G, Gonzalez-Meljem JM, Haston S, Guiho R, Cooper JE, Manshaei S, Jani N, Hölsken A, Pettorini B, Beynon RJ, Simpson DM, Fraser HC, Hong Y, Hallang S, Stone TJ, Virasami A, Donson AM, Jones D, Aquilina K, Spoudeas H, Joshi AR, Grundy R, Storer LCD, Korbonits M, Hilton DA, Tossell K, Thavaraj S, Ungless MA, Gil J, Buslei R, Hankinson T, Hargrave D, Goding C, Andoniadou CL, Brogan P, Jacques TS, Williams HJ, Martinez-Barbera JP. Apps JR, et al. Among authors: carreno g. Acta Neuropathol. 2018 May;135(5):757-777. doi: 10.1007/s00401-018-1830-2. Epub 2018 Mar 14. Acta Neuropathol. 2018. PMID: 29541918 Free PMC article.
SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma.
Carreno G, Boult JKR, Apps J, Gonzalez-Meljem JM, Haston S, Guiho R, Stache C, Danielson LS, Koers A, Smith LM, Virasami A, Panousopoulos L, Buchfelder M, Jacques TS, Chesler L, Robinson SP, Martinez-Barbera JP. Carreno G, et al. Endocr Relat Cancer. 2019 Mar;26(3):355-366. doi: 10.1530/ERC-18-0538. Endocr Relat Cancer. 2019. PMID: 30645190 Free PMC article.
Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans.
Gaston-Massuet C, McCabe MJ, Scagliotti V, Young RM, Carreno G, Gregory LC, Jayakody SA, Pozzi S, Gualtieri A, Basu B, Koniordou M, Wu CI, Bancalari RE, Rahikkala E, Veijola R, Lopponen T, Graziola F, Turton J, Signore M, Mousavy Gharavy SN, Charolidi N, Sokol SY, Andoniadou CL, Wilson SW, Merrill BJ, Dattani MT, Martinez-Barbera JP. Gaston-Massuet C, et al. Among authors: carreno g. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E548-57. doi: 10.1073/pnas.1503346113. Epub 2016 Jan 13. Proc Natl Acad Sci U S A. 2016. PMID: 26764381 Free PMC article.
58 results