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Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration.
Mikami Y, Grubb BR, Rogers TD, Dang H, Asakura T, Kota P, Gilmore RC, Okuda K, Morton LC, Sun L, Chen G, Wykoff JA, Ehre C, Vilar J, van Heusden C, Livraghi-Butrico A, Gentzsch M, Button B, Stutts MJ, Randell SH, O'Neal WK, Boucher RC. Mikami Y, et al. Among authors: van heusden c. Sci Transl Med. 2023 Jun 7;15(699):eabo7728. doi: 10.1126/scitranslmed.abo7728. Epub 2023 Jun 7. Sci Transl Med. 2023. PMID: 37285404
Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia.
van Heusden C, Button B, Anderson WH, Ceppe A, Morton LC, O'Neal WK, Dang H, Alexis NE, Donaldson S, Stephan H, Boucher RC, Lazarowski ER. van Heusden C, et al. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L356-L365. doi: 10.1152/ajplung.00449.2019. Epub 2019 Dec 4. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 31800264 Free PMC article.
Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia.
Seminario-Vidal L, Okada SF, Sesma JI, Kreda SM, van Heusden CA, Zhu Y, Jones LC, O'Neal WK, Penuela S, Laird DW, Boucher RC, Lazarowski ER. Seminario-Vidal L, et al. Among authors: van heusden ca. J Biol Chem. 2011 Jul 29;286(30):26277-86. doi: 10.1074/jbc.M111.260562. Epub 2011 May 23. J Biol Chem. 2011. PMID: 21606493 Free PMC article.
Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness.
Kong X, Bennett WC, Jania CM, Chason KD, German Z, Adouli J, Budney SD, Oby BT, van Heusden C, Lazarowski ER, Jaspers I, Randell SH, Hedgespeth BA, Cruse G, Hua X, Schworer SA, Smith GJ, Kelada SN, Tilley SL. Kong X, et al. Among authors: van heusden c. JCI Insight. 2021 Nov 8;6(21):e140207. doi: 10.1172/jci.insight.140207. JCI Insight. 2021. PMID: 34546976 Free PMC article.
24 results