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Viral emissions into the air and environment after SARS-CoV-2 human challenge: a phase 1, open label, first-in-human study.
Zhou J, Singanayagam A, Goonawardane N, Moshe M, Sweeney FP, Sukhova K, Killingley B, Kalinova M, Mann AJ, Catchpole AP, Barer MR, Ferguson NM, Chiu C, Barclay WS. Zhou J, et al. Among authors: chiu c. Lancet Microbe. 2023 Aug;4(8):e579-e590. doi: 10.1016/S2666-5247(23)00101-5. Epub 2023 Jun 9. Lancet Microbe. 2023. PMID: 37307844 Free PMC article. Clinical Trial.
Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults.
Killingley B, Mann AJ, Kalinova M, Boyers A, Goonawardane N, Zhou J, Lindsell K, Hare SS, Brown J, Frise R, Smith E, Hopkins C, Noulin N, Löndt B, Wilkinson T, Harden S, McShane H, Baillet M, Gilbert A, Jacobs M, Charman C, Mande P, Nguyen-Van-Tam JS, Semple MG, Read RC, Ferguson NM, Openshaw PJ, Rapeport G, Barclay WS, Catchpole AP, Chiu C. Killingley B, et al. Among authors: chiu c. Nat Med. 2022 May;28(5):1031-1041. doi: 10.1038/s41591-022-01780-9. Epub 2022 Mar 31. Nat Med. 2022. PMID: 35361992 Clinical Trial.
Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults.
Wagstaffe HR, Thwaites RS, Reynaldi A, Sidhu JK, McKendry R, Ascough S, Papargyris L, Collins AM, Xu J, Lemm NM, Siggins MK, Chain BM, Killingley B, Kalinova M, Mann A, Catchpole A, Davenport MP, Openshaw PJM, Chiu C. Wagstaffe HR, et al. Among authors: chiu c. Sci Immunol. 2024 Sep 2;9(92):eadj9285. doi: 10.1126/sciimmunol.adj9285. Epub 2024 Feb 9. Sci Immunol. 2024. PMID: 38335268
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection.
Marchal A, Cirulli ET, Neveux I, Bellos E, Thwaites RS, Schiabor Barrett KM, Zhang Y, Nemes-Bokun I, Kalinova M, Catchpole A, Tangye SG, Spaan AN, Lack JB, Ghosn J, Burdet C, Gorochov G, Tubach F, Hausfater P; COVID Human Genetic Effort; COVIDeF Study Group; French COVID Cohort Study Group; CoV-Contact Cohort; COVID-STORM Clinicians; COVID Clinicians; Orchestra Working Group; Amsterdam UMC Covid-19 Biobank; NIAID-USUHS COVID Study Group; Dalgard CL, Zhang SY, Zhang Q, Chiu C, Fellay J, Grzymski JJ, Sancho-Shimizu V, Abel L, Casanova JL, Cobat A, Bolze A. Marchal A, et al. Among authors: chiu c. HGG Adv. 2024 Apr 26:100300. doi: 10.1016/j.xhgg.2024.100300. Online ahead of print. HGG Adv. 2024. PMID: 38678364 Free article.
Safety, tolerability, viral kinetics, and immune correlates of protection in healthy, seropositive UK adults inoculated with SARS-CoV-2: a single-centre, open-label, phase 1 controlled human infection study.
Jackson S, Marshall JL, Mawer A, Lopez-Ramon R, Harris SA, Satti I, Hughes E, Preston-Jones H, Cabrera Puig I, Longet S, Tipton T, Laidlaw S, Doherty RP, Morrison H, Mitchell R, Tanner R, Ateere A, Stylianou E, Wu MS, Fredsgaard-Jones TPW, Breuer J, Rapeport G, Ferreira VM, Gleeson F, Pollard AJ, Carroll M, Catchpole A, Chiu C, McShane H; COV-CHIM01 study team. Jackson S, et al. Among authors: chiu c. Lancet Microbe. 2024 Apr 26:S2666-5247(24)00025-9. doi: 10.1016/S2666-5247(24)00025-9. Online ahead of print. Lancet Microbe. 2024. PMID: 38703782 Free article.
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.
Thwaites RS, Sanchez Sevilla Uruchurtu A, Siggins MK, Liew F, Russell CD, Moore SC, Fairfield C, Carter E, Abrams S, Short CE, Thaventhiran T, Bergstrom E, Gardener Z, Ascough S, Chiu C, Docherty AB, Hunt D, Crow YJ, Solomon T, Taylor GP, Turtle L, Harrison EM, Dunning J, Semple MG, Baillie JK, Openshaw PJ; ISARIC4C investigators. Thwaites RS, et al. Among authors: chiu c. Sci Immunol. 2021 Mar 10;6(57):eabg9873. doi: 10.1126/sciimmunol.abg9873. Sci Immunol. 2021. PMID: 33692097 Free PMC article.
SARS-CoV-2 Human Challenge Studies. Reply.
Rapeport G, Chiu C, McShane H. Rapeport G, et al. Among authors: chiu c. N Engl J Med. 2021 Oct 28;385(18):1728. doi: 10.1056/NEJMc2113574. Epub 2021 Sep 29. N Engl J Med. 2021. PMID: 34587381 No abstract available.
5,460 results