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Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires.
Philippon C, Tao S, Clement D, Haroun-Izquierdo A, Kichula KM, Netskar H, Brandt L, Oei VS, Kanaya M, Lanuza PM, Schaffer M, Goodridge JP, Horowitz A, Zhu F, Hammer Q, Sohlberg E, Majhi RK, Kveberg L, Önfelt B, Norman PJ, Malmberg KJ. Philippon C, et al. Among authors: goodridge jp. Blood Adv. 2023 Aug 22;7(16):4492-4504. doi: 10.1182/bloodadvances.2023009827. Blood Adv. 2023. PMID: 37327114 Free PMC article.
Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.
Cichocki F, Bjordahl R, Goodridge JP, Mahmood S, Gaidarova S, Abujarour R, Davis ZB, Merino A, Tuininga K, Wang H, Kumar A, Groff B, Witty A, Bonello G, Huffman J, Dailey T, Lee TT, Malmberg KJ, Walcheck B, Höpken U, Rehm A, Valamehr B, Miller JS. Cichocki F, et al. Among authors: goodridge jp. Nat Commun. 2022 Nov 29;13(1):7341. doi: 10.1038/s41467-022-35127-2. Nat Commun. 2022. PMID: 36446823 Free PMC article.
Dual antigen-targeted off-the-shelf NK cells show durable response and prevent antigen escape in lymphoma and leukemia.
Cichocki F, Goodridge JP, Bjordahl R, Mahmood S, Davis ZB, Gaidarova S, Abujarour R, Groff B, Witty A, Wang H, Tuininga K, Kodal B, Felices M, Bonello G, Huffman J, Dailey T, Lee TT, Walcheck B, Valamehr B, Miller JS. Cichocki F, et al. Among authors: goodridge jp. Blood. 2022 Dec 8;140(23):2451-2462. doi: 10.1182/blood.2021015184. Blood. 2022. PMID: 35917442 Free PMC article.
Genetic ablation of adhesion ligands averts rejection of allogeneic immune cells.
Hammer Q, Perica K, van Ooijen H, Mbofung R, Momayyezi P, Varady E, Martin KE, Pan Y, Jelcic M, Groff B, Abujarour R, Krokeide S, Lee T, Williams A, Goodridge JP, Valamehr B, Önfelt B, Sadelain M, Malmberg KJ. Hammer Q, et al. Among authors: goodridge jp. bioRxiv [Preprint]. 2023 Oct 9:2023.10.09.557143. doi: 10.1101/2023.10.09.557143. bioRxiv. 2023. PMID: 37873468 Free PMC article. Preprint.
Remodeling of secretory lysosomes during education tunes functional potential in NK cells.
Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ. Goodridge JP, et al. Nat Commun. 2019 Jan 31;10(1):514. doi: 10.1038/s41467-019-08384-x. Nat Commun. 2019. PMID: 30705279 Free PMC article.
Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans.
Liu LL, Landskron J, Ask EH, Enqvist M, Sohlberg E, Traherne JA, Hammer Q, Goodridge JP, Larsson S, Jayaraman J, Oei VYS, Schaffer M, Taskén K, Ljunggren HG, Romagnani C, Trowsdale J, Malmberg KJ, Béziat V. Liu LL, et al. Among authors: goodridge jp. Cell Rep. 2016 May 3;15(5):1088-1099. doi: 10.1016/j.celrep.2016.04.005. Epub 2016 Apr 21. Cell Rep. 2016. PMID: 27117418 Free PMC article.
43 results