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Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages.
Taddei RN, Sanchez-Mico MV, Bonnar O, Connors T, Gaona A, Denbow D, Frosch MP, Gómez-Isla T. Taddei RN, et al. Among authors: bonnar o. Acta Neuropathol Commun. 2022 May 9;10(1):72. doi: 10.1186/s40478-022-01370-3. Acta Neuropathol Commun. 2022. PMID: 35534858 Free PMC article.
A multi-hit hypothesis for an APOE4-dependent pathophysiological state.
Steele OG, Stuart AC, Minkley L, Shaw K, Bonnar O, Anderle S, Penn AC, Rusted J, Serpell L, Hall C, King S. Steele OG, et al. Among authors: bonnar o. Eur J Neurosci. 2022 Nov;56(9):5476-5515. doi: 10.1111/ejn.15685. Epub 2022 Jun 6. Eur J Neurosci. 2022. PMID: 35510513 Free PMC article. Review.
First, tau causes NO problem.
Bonnar O, Hall CN. Bonnar O, et al. Nat Neurosci. 2020 Sep;23(9):1035-1036. doi: 10.1038/s41593-020-0691-x. Nat Neurosci. 2020. PMID: 32778790 No abstract available.