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Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy.
Fejzo M, Rocha N, Cimino I, Lockhart SM, Petry C, Kay RG, Burling K, Barker P, George AL, Yasara N, Premawardhena A, Gong S, Cook E, Rainbow K, Withers DJ, Cortessis V, Mullin PM, MacGibbon KW, Jin E, Kam A, Campbell A, Polasek O, Tzoneva G, Gribble FM, Yeo G, Lam B, Saudek V, Hughes IA, Ong KK, Perry J, Sutton Cole A, Baumgarten M, Welsh P, Sattar N, Smith G, Charnock Jones DS, Coll AP, Meek CL, Mettananda S, Hayward C, Mancuso N, O'Rahilly S. Fejzo M, et al. Among authors: mancuso n. bioRxiv [Preprint]. 2023 Jun 4:2023.06.02.542661. doi: 10.1101/2023.06.02.542661. bioRxiv. 2023. PMID: 37398065 Free PMC article. Preprint.
Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum.
Fejzo MS, Sazonova OV, Sathirapongsasuti JF, Hallgrímsdóttir IB, Vacic V, MacGibbon KW, Schoenberg FP, Mancuso N, Slamon DJ, Mullin PM; 23andMe Research Team. Fejzo MS, et al. Among authors: mancuso n. Nat Commun. 2018 Mar 21;9(1):1178. doi: 10.1038/s41467-018-03258-0. Nat Commun. 2018. PMID: 29563502 Free PMC article.
Tree-based QTL mapping with expected local genetic relatedness matrices.
Link V, Schraiber JG, Fan C, Dinh B, Mancuso N, Chiang CWK, Edge MD. Link V, et al. Among authors: mancuso n. bioRxiv [Preprint]. 2023 Apr 8:2023.04.07.536093. doi: 10.1101/2023.04.07.536093. bioRxiv. 2023. PMID: 37066144 Free PMC article. Updated. Preprint.
GDF15 linked to maternal risk of nausea and vomiting during pregnancy.
Fejzo M, Rocha N, Cimino I, Lockhart SM, Petry CJ, Kay RG, Burling K, Barker P, George AL, Yasara N, Premawardhena A, Gong S, Cook E, Rimmington D, Rainbow K, Withers DJ, Cortessis V, Mullin PM, MacGibbon KW, Jin E, Kam A, Campbell A, Polasek O, Tzoneva G, Gribble FM, Yeo GSH, Lam BYH, Saudek V, Hughes IA, Ong KK, Perry JRB, Sutton Cole A, Baumgarten M, Welsh P, Sattar N, Smith GCS, Charnock-Jones DS, Coll AP, Meek CL, Mettananda S, Hayward C, Mancuso N, O'Rahilly S. Fejzo M, et al. Among authors: mancuso n. Nature. 2024 Jan;625(7996):760-767. doi: 10.1038/s41586-023-06921-9. Epub 2023 Dec 13. Nature. 2024. PMID: 38092039 Free PMC article.
Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics.
Chan TF, Rui X, Conti DV, Fornage M, Graff M, Haessler J, Haiman C, Highland HM, Jung SY, Kenny E, Kooperberg C, Marchland LL, North KE, Tao R, Wojcik G, Gignoux CR; PAGE Consortium; Chiang CWK, Mancuso N. Chan TF, et al. Among authors: mancuso n. bioRxiv [Preprint]. 2023 Apr 18:2023.04.10.536252. doi: 10.1101/2023.04.10.536252. bioRxiv. 2023. PMID: 37131817 Free PMC article. Updated. Preprint.
Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization.
Pathak GA, Singh K, Miller-Fleming TW, Wendt FR, Ehsan N, Hou K, Johnson R, Lu Z, Gopalan S, Yengo L, Mohammadi P, Pasaniuc B, Polimanti R, Davis LK, Mancuso N. Pathak GA, et al. Among authors: mancuso n. medRxiv [Preprint]. 2020 Dec 8:2020.12.07.20245308. doi: 10.1101/2020.12.07.20245308. medRxiv. 2020. PMID: 33330876 Free PMC article. Updated. Preprint.
87 results