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The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy.
McMyn NF, Varriale J, Fray EJ, Zitzmann C, MacLeod H, Lai J, Singhal A, Moskovljevic M, Garcia MA, Lopez BM, Hariharan V, Rhodehouse K, Lynn K, Tebas P, Mounzer K, Montaner LJ, Benko E, Kovacs C, Hoh R, Simonetti FR, Laird GM, Deeks SG, Ribeiro RM, Perelson AS, Siliciano RF, Siliciano JM. McMyn NF, et al. Among authors: kovacs c. J Clin Invest. 2023 Sep 1;133(17):e171554. doi: 10.1172/JCI171554. J Clin Invest. 2023. PMID: 37463049 Free PMC article.
Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.
Huang SH, Ren Y, Thomas AS, Chan D, Mueller S, Ward AR, Patel S, Bollard CM, Cruz CR, Karandish S, Truong R, Macedo AB, Bosque A, Kovacs C, Benko E, Piechocka-Trocha A, Wong H, Jeng E, Nixon DF, Ho YC, Siliciano RF, Walker BD, Jones RB. Huang SH, et al. Among authors: kovacs c. J Clin Invest. 2018 Feb 1;128(2):876-889. doi: 10.1172/JCI97555. Epub 2018 Jan 22. J Clin Invest. 2018. PMID: 29355843 Free PMC article.
Intensifying Antiretroviral Therapy With Raltegravir and Maraviroc During Early Human Immunodeficiency Virus (HIV) Infection Does Not Accelerate HIV Reservoir Reduction.
Ostrowski M, Benko E, Yue FY, Kim CJ, Huibner S, Lee T, Singer J, Pankovich J, Laeyendecker O, Kaul R, Kandel G, Kovacs C. Ostrowski M, et al. Among authors: kovacs c. Open Forum Infect Dis. 2015 Sep 22;2(4):ofv138. doi: 10.1093/ofid/ofv138. eCollection 2015 Dec. Open Forum Infect Dis. 2015. PMID: 26512359 Free PMC article.
Effect of antiretroviral therapy on HIV reservoirs in elite controllers.
Chun TW, Shawn Justement J, Murray D, Kim CJ, Blazkova J, Hallahan CW, Benko E, Costiniuk CT, Kandel G, Ostrowski M, Kaul R, Moir S, Casazza JP, Koup RA, Kovacs C, Fauci AS. Chun TW, et al. Among authors: kovacs c. J Infect Dis. 2013 Nov 1;208(9):1443-7. doi: 10.1093/infdis/jit306. Epub 2013 Jul 11. J Infect Dis. 2013. PMID: 23847057 Free PMC article.
HIV RNA Rebound in Seminal Plasma after Antiretroviral Treatment Interruption.
Gianella S, Chaillon A, Chun TW, Sneller MC, Ignacio C, Vargas-Meneses MV, Caballero G, Ellis RJ, Kovacs C, Benko E, Huibner S, Kaul R. Gianella S, et al. Among authors: kovacs c. J Virol. 2020 Jul 16;94(15):e00415-20. doi: 10.1128/JVI.00415-20. Print 2020 Jul 16. J Virol. 2020. PMID: 32434884 Free PMC article. Clinical Trial.
Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir.
Chun TW, Murray D, Justement JS, Blazkova J, Hallahan CW, Fankuchen O, Gittens K, Benko E, Kovacs C, Moir S, Fauci AS. Chun TW, et al. Among authors: kovacs c. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13151-6. doi: 10.1073/pnas.1414148111. Epub 2014 Aug 25. Proc Natl Acad Sci U S A. 2014. PMID: 25157148 Free PMC article.
Antiretroviral therapy in HIV-infected elite controllers: impact on gut immunology, microbial translocation, and biomarkers of serious non-AIDS conditions.
Kim CJ, Kovacs C, Chun TW, Kandel G, Osborne BJ, Huibner S, Shahabi K, Yue FY, Benko E, Ostowski M, Kaul R. Kim CJ, et al. Among authors: kovacs c. J Acquir Immune Defic Syndr. 2014 Dec 15;67(5):514-8. doi: 10.1097/QAI.0000000000000359. J Acquir Immune Defic Syndr. 2014. PMID: 25393939 Free PMC article.
508 results