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Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice.
Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH 3rd, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, Graham RL, Perry JK, Du Pont V, Pitts J, Ma B, Babusis D, Murakami E, Feng JY, Bilello JP, Porter DP, Cihlar T, Baric RS, Denison MR, Sheahan TP. Pruijssers AJ, et al. Among authors: perry jk. Cell Rep. 2020 Jul 21;32(3):107940. doi: 10.1016/j.celrep.2020.107940. Epub 2020 Jul 7. Cell Rep. 2020. PMID: 32668216 Free PMC article.
Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases.
Lo MK, Albariño CG, Perry JK, Chang S, Tchesnokov EP, Guerrero L, Chakrabarti A, Shrivastava-Ranjan P, Chatterjee P, McMullan LK, Martin R, Jordan R, Götte M, Montgomery JM, Nichol ST, Flint M, Porter D, Spiropoulou CF. Lo MK, et al. Among authors: perry jk. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26946-26954. doi: 10.1073/pnas.2012294117. Epub 2020 Oct 7. Proc Natl Acad Sci U S A. 2020. PMID: 33028676 Free PMC article.
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.
Stevens LJ, Pruijssers AJ, Lee HW, Gordon CJ, Tchesnokov EP, Gribble J, George AS, Hughes TM, Lu X, Li J, Perry JK, Porter DP, Cihlar T, Sheahan TP, Baric RS, Götte M, Denison MR. Stevens LJ, et al. Among authors: perry jk. Sci Transl Med. 2022 Aug 3;14(656):eabo0718. doi: 10.1126/scitranslmed.abo0718. Epub 2022 Aug 3. Sci Transl Med. 2022. PMID: 35482820 Free PMC article.
111 results