Tyzack G - Search Results

1

Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition.

Ziff OJ, Harley J, Wang Y, Neeves J, Tyzack G, Ibrahim F, Skehel M, Chakrabarti AM, Kelly G, Patani R. Ziff OJ, et al. Among authors: tyzack g. Neuron. 2023 Oct 4;111(19):3011-3027.e7. doi: 10.1016/j.neuron.2023.06.019. Epub 2023 Jul 21. Neuron. 2023. PMID: 37480846 Free article.

2

Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength.

Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky AV, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH. Kelley KW, et al. Among authors: tyzack ge. Neuron. 2018 Apr 18;98(2):306-319.e7. doi: 10.1016/j.neuron.2018.03.010. Epub 2018 Apr 5. Neuron. 2018. PMID: 29606582 Free PMC article.

3

Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis.

Tyzack GE, Luisier R, Taha DM, Neeves J, Modic M, Mitchell JS, Meyer I, Greensmith L, Newcombe J, Ule J, Luscombe NM, Patani R. Tyzack GE, et al. Brain. 2019 Sep 1;142(9):2572-2580. doi: 10.1093/brain/awz217. Brain. 2019. PMID: 31368485 Free PMC article.

4

Reactive astrocytes in ALS display diminished intron retention.

Ziff OJ, Taha DM, Crerar H, Clarke BE, Chakrabarti AM, Kelly G, Neeves J, Tyzack GE, Luscombe NM, Patani R. Ziff OJ, et al. Among authors: tyzack ge. Nucleic Acids Res. 2021 Apr 6;49(6):3168-3184. doi: 10.1093/nar/gkab115. Nucleic Acids Res. 2021. PMID: 33684213 Free PMC article.

5

Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis.

Tyzack GE, Neeves J, Crerar H, Klein P, Ziff O, Taha DM, Luisier R, Luscombe NM, Patani R. Tyzack GE, et al. Brain. 2021 Aug 17;144(7):1985-1993. doi: 10.1093/brain/awab078. Brain. 2021. PMID: 33693641 Free PMC article.

6

Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis.

Petrić Howe M, Crerar H, Neeves J, Harley J, Tyzack GE, Klein P, Ramos A, Patani R, Luisier R. Petrić Howe M, et al. Among authors: tyzack ge. Genome Res. 2022 Oct;32(10):1808-1825. doi: 10.1101/gr.276898.122. Epub 2022 Sep 30. Genome Res. 2022. PMID: 36180233 Free PMC article.

7

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology.

Ziff OJ, Neeves J, Mitchell J, Tyzack G, Martinez-Ruiz C, Luisier R, Chakrabarti AM, McGranahan N, Litchfield K, Boulton SJ, Al-Chalabi A, Kelly G, Humphrey J, Patani R. Ziff OJ, et al. Among authors: tyzack g. Nat Commun. 2023 Apr 20;14(1):2176. doi: 10.1038/s41467-023-37630-6. Nat Commun. 2023. PMID: 37080969 Free PMC article.

8

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS.

Hall CE, Yao Z, Choi M, Tyzack GE, Serio A, Luisier R, Harley J, Preza E, Arber C, Crisp SJ, Watson PMD, Kullmann DM, Abramov AY, Wray S, Burley R, Loh SHY, Martins LM, Stevens MM, Luscombe NM, Sibley CR, Lakatos A, Ule J, Gandhi S, Patani R. Hall CE, et al. Cell Rep. 2017 May 30;19(9):1739-1749. doi: 10.1016/j.celrep.2017.05.024. Cell Rep. 2017. PMID: 28564594 Free PMC article.

9

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis.

Taha DM, Clarke BE, Hall CE, Tyzack GE, Ziff OJ, Greensmith L, Kalmar B, Ahmed M, Alam A, Thelin EP, Garcia NM, Helmy A, Sibley CR, Patani R. Taha DM, et al. Among authors: tyzack ge. Brain. 2022 Apr 18;145(2):481-489. doi: 10.1093/brain/awab328. Brain. 2022. PMID: 35042241 Free PMC article.

10

A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models.

Tyzack GE, Hall CE, Sibley CR, Cymes T, Forostyak S, Carlino G, Meyer IF, Schiavo G, Zhang SC, Gibbons GM, Newcombe J, Patani R, Lakatos A. Tyzack GE, et al. Nat Commun. 2017 Oct 27;8(1):1164. doi: 10.1038/s41467-017-01283-z. Nat Commun. 2017. PMID: 29079839 Free PMC article.

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