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Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair.
Martinez Lagunas K, Savcigil DP, Zrilic M, Carvajal Fraile C, Craxton A, Self E, Uranga-Murillo I, de Miguel D, Arias M, Willenborg S, Piekarek M, Albert MC, Nugraha K, Lisewski I, Janakova E, Igual N, Tonnus W, Hildebrandt X, Ibrahim M, Ballegeer M, Saelens X, Kueh A, Meier P, Linkermann A, Pardo J, Eming S, Walczak H, MacFarlane M, Peltzer N, Annibaldi A. Martinez Lagunas K, et al. Among authors: tonnus w. Sci Adv. 2023 Jul 28;9(30):eadg2829. doi: 10.1126/sciadv.adg2829. Epub 2023 Jul 26. Sci Adv. 2023. PMID: 37494451 Free PMC article.
The in vivo evidence for regulated necrosis.
Tonnus W, Linkermann A. Tonnus W, et al. Immunol Rev. 2017 May;277(1):128-149. doi: 10.1111/imr.12551. Immunol Rev. 2017. PMID: 28462528 Review.
Die later with ESCRT!
Tonnus W, Gembardt F, Hugo C, Linkermann A. Tonnus W, et al. Oncotarget. 2017 Jun 27;8(26):41790-41791. doi: 10.18632/oncotarget.17903. Oncotarget. 2017. PMID: 28574845 Free PMC article. No abstract available.
Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury.
Martens S, Jeong M, Tonnus W, Feldmann F, Hofmans S, Goossens V, Takahashi N, Bräsen JH, Lee EW, Van der Veken P, Joossens J, Augustyns K, Fulda S, Linkermann A, Song J, Vandenabeele P. Martens S, et al. Among authors: tonnus w. Cell Death Dis. 2017 Jun 29;8(6):e2904. doi: 10.1038/cddis.2017.298. Cell Death Dis. 2017. PMID: 28661484 Free PMC article.
Origin and Consequences of Necroinflammation.
Sarhan M, Land WG, Tonnus W, Hugo CP, Linkermann A. Sarhan M, et al. Among authors: tonnus w. Physiol Rev. 2018 Apr 1;98(2):727-780. doi: 10.1152/physrev.00041.2016. Physiol Rev. 2018. PMID: 29465288 Free article. Review.
35 results