Tanzi R - Search Results

1

Optimizing animal models of autoimmune encephalitis using active immunization.

Linnoila J, Jalali Motlagh N, Jachimiec G, Lin CJ, Küllenberg E, Wojtkiewicz G, Tanzi R, Chen JW. Linnoila J, et al. Among authors: tanzi r. Front Immunol. 2023 Jul 12;14:1177672. doi: 10.3389/fimmu.2023.1177672. eCollection 2023. Front Immunol. 2023. PMID: 37520559 Free PMC article.

2

Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice.

Lin CJ, Herisson F, Le H, Jaafar N, Chetal K, Oram MK, Flynn KL, Gavrilles EP, Sadreyev RI, Schiffino FL, Tanzi RE. Lin CJ, et al. Cell Rep. 2023 Sep 26;42(9):113141. doi: 10.1016/j.celrep.2023.113141. Epub 2023 Sep 19. Cell Rep. 2023. PMID: 37713312 Free PMC article.

3

Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease.

Boyarko B, Podvin S, Greenberg B, Momper JD, Huang Y, Gerwick WH, Bang AG, Quinti L, Griciuc A, Kim DY, Tanzi RE, Feldman HH, Hook V. Boyarko B, et al. Front Pharmacol. 2023 Aug 4;14:1190402. doi: 10.3389/fphar.2023.1190402. eCollection 2023. Front Pharmacol. 2023. PMID: 37601062 Free PMC article. Review.

4

Accelerating the in vitro emulation of Alzheimer's disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model.

Ko EC, Spitz S, Pramotton FM, Barr OM, Xu C, Pavlou G, Zhang S, Tsai A, Maaser-Hecker A, Jorfi M, Choi SH, Tanzi RE, Kamm RD. Ko EC, et al. Front Bioeng Biotechnol. 2023 Oct 9;11:1251195. doi: 10.3389/fbioe.2023.1251195. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 37901842 Free PMC article.

5

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models.

Wittrahm R, Takalo M, Kuulasmaa T, Mäkinen PM, Mäkinen P, Končarević S, Fartzdinov V, Selzer S, Kokkola T, Antikainen L, Martiskainen H, Kemppainen S, Marttinen M, Jeskanen H, Rostalski H, Rahunen E, Kivipelto M, Ngandu T, Natunen T, Lambert JC, Tanzi RE, Kim DY, Rauramaa T, Herukka SK, Soininen H, Laakso M, Pike I, Leinonen V, Haapasalo A, Hiltunen M. Wittrahm R, et al. Among authors: tanzi re. Neurobiol Dis. 2023 Jun 15;182:106140. doi: 10.1016/j.nbd.2023.106140. Epub 2023 Apr 28. Neurobiol Dis. 2023. PMID: 37120095 Free article.

6

Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling.

Kim E, Kim H, Jedrychowski MP, Bakiasi G, Park J, Kruskop J, Choi Y, Kwak SS, Quinti L, Kim DY, Wrann CD, Spiegelman BM, Tanzi RE, Choi SH. Kim E, et al. Neuron. 2023 Nov 15;111(22):3619-3633.e8. doi: 10.1016/j.neuron.2023.08.012. Epub 2023 Sep 8. Neuron. 2023. PMID: 37689059 Free article.

7

Bioluminescence Imaging with Functional Amyloid Reservoirs in Alzheimer's Disease Models.

Yang J, Ding W, Zhu B, Zhen S, Kuang S, Yang J, Zhang C, Wang P, Yang F, Yang L, Yin W, Tanzi RE, Shen S, Ran C. Yang J, et al. Anal Chem. 2023 Sep 26;95(38):14261-14270. doi: 10.1021/acs.analchem.3c02358. Epub 2023 Sep 15. Anal Chem. 2023. PMID: 37712902

8

Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors.

Liu G, Mondal P, Sang N, Li Z, Ding W, Yang L, Liu Y, Birar VC, Gomm A, Tanzi RE, Zhang C, Shen S, Wang C, Lu X, Bai P. Liu G, et al. Eur J Med Chem. 2023 Jun 5;254:115327. doi: 10.1016/j.ejmech.2023.115327. Epub 2023 Mar 31. Eur J Med Chem. 2023. PMID: 37098307

9

Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice.

Bai P, Liu Y, Yang L, Ding W, Mondal P, Sang N, Liu G, Lu X, Ho TT, Zhou Y, Wu R, Birar VC, Wilks MQ, Tanzi RE, Lin H, Zhang C, Li W, Shen S, Wang C. Bai P, et al. Among authors: tanzi re. J Med Chem. 2023 Dec 14;66(23):16075-16090. doi: 10.1021/acs.jmedchem.3c01491. Epub 2023 Nov 16. J Med Chem. 2023. PMID: 37972387

10

Design and Discovery of Novel NLRP3 Inhibitors and PET Imaging Radiotracers Based on a 1,2,3-Triazole-Bearing Scaffold.

Xu Y, Xu Y, Biby S, Kaur B, Liu Y, Bagdasarian FA, Wey HY, Tanzi R, Zhang C, Wang C, Zhang S. Xu Y, et al. Among authors: tanzi r. J Med Chem. 2024 Jan 11;67(1):555-571. doi: 10.1021/acs.jmedchem.3c01782. Epub 2023 Dec 27. J Med Chem. 2024. PMID: 38150705 Free PMC article.

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