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Catalytic inhibitor of Protein Phosphatase 5 activates the extrinsic apoptotic pathway by disrupting complex II in kidney cancer.
Ahanin EF, Sager RA, Backe SJ, Dunn DM, Dushukyan N, Blanden AR, Mate NA, Suzuki T, Anderson T, Roy M, Oberoi J, Prodromou C, Nsouli I, Daneshvar M, Bratslavsky G, Woodford MR, Bourboulia D, Chisholm JD, Mollapour M. Ahanin EF, et al. Among authors: backe sj. Cell Chem Biol. 2023 Oct 19;30(10):1223-1234.e12. doi: 10.1016/j.chembiol.2023.06.026. Epub 2023 Jul 31. Cell Chem Biol. 2023. PMID: 37527661
Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90.
Sager RA, Woodford MR, Backe SJ, Makedon AM, Baker-Williams AJ, DiGregorio BT, Loiselle DR, Haystead TA, Zachara NE, Prodromou C, Bourboulia D, Schmidt LS, Linehan WM, Bratslavsky G, Mollapour M. Sager RA, et al. Among authors: backe sj. Cell Rep. 2019 Jan 29;26(5):1344-1356.e5. doi: 10.1016/j.celrep.2019.01.018. Cell Rep. 2019. PMID: 30699359 Free PMC article.
Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity.
Woodford MR, Hughes M, Sager RA, Backe SJ, Baker-Williams AJ, Bratslavsky MS, Jacob JM, Shapiro O, Wong M, Bratslavsky G, Bourboulia D, Mollapour M. Woodford MR, et al. Among authors: backe sj. Oncotarget. 2019 Oct 8;10(56):5824-5834. doi: 10.18632/oncotarget.27217. eCollection 2019 Oct 8. Oncotarget. 2019. PMID: 31645902 Free PMC article.
Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90-Client Interactions.
Paladino A, Woodford MR, Backe SJ, Sager RA, Kancherla P, Daneshvar MA, Chen VZ, Bourboulia D, Ahanin EF, Prodromou C, Bergamaschi G, Strada A, Cretich M, Gori A, Veronesi M, Bandiera T, Vanna R, Bratslavsky G, Serapian SA, Mollapour M, Colombo G. Paladino A, et al. Among authors: backe sj. Chemistry. 2020 Aug 3;26(43):9459-9465. doi: 10.1002/chem.202000615. Epub 2020 Jul 8. Chemistry. 2020. PMID: 32167602 Free PMC article.
The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
Woodford MR, Baker-Williams AJ, Sager RA, Backe SJ, Blanden AR, Hashmi F, Kancherla P, Gori A, Loiselle DR, Castelli M, Serapian SA, Colombo G, Haystead TA, Jensen SM, Stetler-Stevenson WG, Loh SN, Schmidt LS, Linehan WM, Bah A, Bourboulia D, Bratslavsky G, Mollapour M. Woodford MR, et al. Among authors: backe sj. Nat Struct Mol Biol. 2021 Aug;28(8):662-670. doi: 10.1038/s41594-021-00633-2. Epub 2021 Aug 11. Nat Struct Mol Biol. 2021. PMID: 34381247 Free PMC article.
Therapeutic potential of CDK4/6 inhibitors in renal cell carcinoma.
Sager RA, Backe SJ, Ahanin E, Smith G, Nsouli I, Woodford MR, Bratslavsky G, Bourboulia D, Mollapour M. Sager RA, et al. Among authors: backe sj. Nat Rev Urol. 2022 May;19(5):305-320. doi: 10.1038/s41585-022-00571-8. Epub 2022 Mar 9. Nat Rev Urol. 2022. PMID: 35264774 Free PMC article. Review.
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