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Catalytic inhibitor of Protein Phosphatase 5 activates the extrinsic apoptotic pathway by disrupting complex II in kidney cancer.
Ahanin EF, Sager RA, Backe SJ, Dunn DM, Dushukyan N, Blanden AR, Mate NA, Suzuki T, Anderson T, Roy M, Oberoi J, Prodromou C, Nsouli I, Daneshvar M, Bratslavsky G, Woodford MR, Bourboulia D, Chisholm JD, Mollapour M. Ahanin EF, et al. Among authors: sager ra. Cell Chem Biol. 2023 Oct 19;30(10):1223-1234.e12. doi: 10.1016/j.chembiol.2023.06.026. Epub 2023 Jul 31. Cell Chem Biol. 2023. PMID: 37527661
Loss of Wave1 gene defines a subtype of lethal prostate cancer.
Sowalsky AG, Sager R, Schaefer RJ, Bratslavsky G, Pandolfi PP, Balk SP, Kotula L. Sowalsky AG, et al. Oncotarget. 2015 May 20;6(14):12383-91. doi: 10.18632/oncotarget.3564. Oncotarget. 2015. PMID: 25906751 Free PMC article.
Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M. Woodford MR, et al. Among authors: sager ra. EMBO J. 2017 Dec 15;36(24):3650-3665. doi: 10.15252/embj.201796700. Epub 2017 Nov 10. EMBO J. 2017. PMID: 29127155 Free PMC article.
Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.
Dushukyan N, Dunn DM, Sager RA, Woodford MR, Loiselle DR, Daneshvar M, Baker-Williams AJ, Chisholm JD, Truman AW, Vaughan CK, Haystead TA, Bratslavsky G, Bourboulia D, Mollapour M. Dushukyan N, et al. Among authors: sager ra. Cell Rep. 2017 Nov 14;21(7):1883-1895. doi: 10.1016/j.celrep.2017.10.074. Cell Rep. 2017. PMID: 29141220 Free PMC article.
Detecting Posttranslational Modifications of Hsp90.
Sager RA, Woodford MR, Neckers L, Mollapour M. Sager RA, et al. Methods Mol Biol. 2018;1709:209-219. doi: 10.1007/978-1-4939-7477-1_16. Methods Mol Biol. 2018. PMID: 29177662 Free PMC article.
The mTOR Independent Function of Tsc1 and FNIPs.
Sager RA, Woodford MR, Mollapour M. Sager RA, et al. Trends Biochem Sci. 2018 Dec;43(12):935-937. doi: 10.1016/j.tibs.2018.09.018. Epub 2018 Oct 22. Trends Biochem Sci. 2018. PMID: 30361061 Free PMC article.
Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90.
Sager RA, Woodford MR, Backe SJ, Makedon AM, Baker-Williams AJ, DiGregorio BT, Loiselle DR, Haystead TA, Zachara NE, Prodromou C, Bourboulia D, Schmidt LS, Linehan WM, Bratslavsky G, Mollapour M. Sager RA, et al. Cell Rep. 2019 Jan 29;26(5):1344-1356.e5. doi: 10.1016/j.celrep.2019.01.018. Cell Rep. 2019. PMID: 30699359 Free PMC article.
Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity.
Woodford MR, Hughes M, Sager RA, Backe SJ, Baker-Williams AJ, Bratslavsky MS, Jacob JM, Shapiro O, Wong M, Bratslavsky G, Bourboulia D, Mollapour M. Woodford MR, et al. Among authors: sager ra. Oncotarget. 2019 Oct 8;10(56):5824-5834. doi: 10.18632/oncotarget.27217. eCollection 2019 Oct 8. Oncotarget. 2019. PMID: 31645902 Free PMC article.
Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90-Client Interactions.
Paladino A, Woodford MR, Backe SJ, Sager RA, Kancherla P, Daneshvar MA, Chen VZ, Bourboulia D, Ahanin EF, Prodromou C, Bergamaschi G, Strada A, Cretich M, Gori A, Veronesi M, Bandiera T, Vanna R, Bratslavsky G, Serapian SA, Mollapour M, Colombo G. Paladino A, et al. Among authors: sager ra. Chemistry. 2020 Aug 3;26(43):9459-9465. doi: 10.1002/chem.202000615. Epub 2020 Jul 8. Chemistry. 2020. PMID: 32167602 Free PMC article.
27 results