Sarathy JP - Search Results

1

Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses.

Walter ND, Ernest JP, Dide-Agossou C, Bauman AA, Ramey ME, Rossmassler K, Massoudi LM, Pauly S, Al Mubarak R, Voskuil MI, Kaya F, Sarathy JP, Zimmerman MD, Dartois V, Podell BK, Savic RM, Robertson GT. Walter ND, et al. Among authors: sarathy jp. Antimicrob Agents Chemother. 2023 Sep 19;67(9):e0028423. doi: 10.1128/aac.00284-23. Epub 2023 Aug 11. Antimicrob Agents Chemother. 2023. PMID: 37565762 Free PMC article.

2

Reduced drug uptake in phenotypically resistant nutrient-starved nonreplicating Mycobacterium tuberculosis.

Sarathy J, Dartois V, Dick T, Gengenbacher M. Sarathy J, et al. Antimicrob Agents Chemother. 2013 Apr;57(4):1648-53. doi: 10.1128/AAC.02202-12. Epub 2013 Jan 18. Antimicrob Agents Chemother. 2013. PMID: 23335744 Free PMC article.

3

Polyamines inhibit porin-mediated fluoroquinolone uptake in mycobacteria.

Sarathy JP, Lee E, Dartois V. Sarathy JP, et al. PLoS One. 2013 Jun 3;8(6):e65806. doi: 10.1371/journal.pone.0065806. Print 2013. PLoS One. 2013. PMID: 23755283 Free PMC article.

4

The role of transport mechanisms in mycobacterium tuberculosis drug resistance and tolerance.

Sarathy JP, Dartois V, Lee EJ. Sarathy JP, et al. Pharmaceuticals (Basel). 2012 Nov 9;5(11):1210-35. doi: 10.3390/ph5111210. Pharmaceuticals (Basel). 2012. PMID: 24281307 Free PMC article.

5

The association between sterilizing activity and drug distribution into tuberculosis lesions.

Prideaux B, Via LE, Zimmerman MD, Eum S, Sarathy J, O'Brien P, Chen C, Kaya F, Weiner DM, Chen PY, Song T, Lee M, Shim TS, Cho JS, Kim W, Cho SN, Olivier KN, Barry CE 3rd, Dartois V. Prideaux B, et al. Nat Med. 2015 Oct;21(10):1223-7. doi: 10.1038/nm.3937. Epub 2015 Sep 7. Nat Med. 2015. PMID: 26343800 Free PMC article.

6

High Systemic Exposure of Pyrazinoic Acid Has Limited Antituberculosis Activity in Murine and Rabbit Models of Tuberculosis.

Lanoix JP, Tasneen R, O'Brien P, Sarathy J, Safi H, Pinn M, Alland D, Dartois V, Nuermberger E. Lanoix JP, et al. Among authors: sarathy j. Antimicrob Agents Chemother. 2016 Jun 20;60(7):4197-205. doi: 10.1128/AAC.03085-15. Print 2016 Jul. Antimicrob Agents Chemother. 2016. PMID: 27139472 Free PMC article.

7

Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis.

Gopal P, Yee M, Sarathy J, Low JL, Sarathy JP, Kaya F, Dartois V, Gengenbacher M, Dick T. Gopal P, et al. Among authors: sarathy j, sarathy jp. ACS Infect Dis. 2016 Sep 9;2(9):616-626. doi: 10.1021/acsinfecdis.6b00070. Epub 2016 Aug 8. ACS Infect Dis. 2016. PMID: 27759369 Free PMC article.

8

In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.

Gopal P, Tasneen R, Yee M, Lanoix JP, Sarathy J, Rasic G, Li L, Dartois V, Nuermberger E, Dick T. Gopal P, et al. Among authors: sarathy j. ACS Infect Dis. 2017 Jul 14;3(7):492-501. doi: 10.1021/acsinfecdis.7b00017. Epub 2017 Mar 16. ACS Infect Dis. 2017. PMID: 28271875 Free PMC article.

9

An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions.

Sarathy JP, Liang HH, Weiner D, Gonzales J, Via LE, Dartois V. Sarathy JP, et al. J Vis Exp. 2017 May 8;(123):55559. doi: 10.3791/55559. J Vis Exp. 2017. PMID: 28518128 Free PMC article.

10

Ethambutol Partitioning in Tuberculous Pulmonary Lesions Explains Its Clinical Efficacy.

Zimmerman M, Lestner J, Prideaux B, O'Brien P, Dias-Freedman I, Chen C, Dietzold J, Daudelin I, Kaya F, Blanc L, Chen PY, Park S, Salgame P, Sarathy J, Dartois V. Zimmerman M, et al. Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00924-17. doi: 10.1128/AAC.00924-17. Print 2017 Sep. Antimicrob Agents Chemother. 2017. PMID: 28696241 Free PMC article.

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