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Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.
Vande Voorde J, Steven RT, Najumudeen AK, Ford CA, Dexter A, Gonzalez-Fernandez A, Nikula CJ, Xiang Y, Ford L, Maneta Stavrakaki S, Gilroy K, Zeiger LB, Pennel K, Hatthakarnkul P, Elia EA, Nasif A, Murta T, Manoli E, Mason S, Gillespie M, Lannagan TRM, Vlahov N, Ridgway RA, Nixon C, Raven A, Mills M, Athineos D, Kanellos G, Nourse C, Gay DM, Hughes M, Burton A, Yan B, Sellers K, Wu V, De Ridder K, Shokry E, Huerta Uribe A, Clark W, Clark G, Kirschner K, Thienpont B, Li VSW, Maddocks ODK, Barry ST, Goodwin RJA, Kinross J, Edwards J, Yuneva MO, Sumpton D, Takats Z, Campbell AD, Bunch J, Sansom OJ. Vande Voorde J, et al. Among authors: hughes m. Nat Metab. 2023 Aug;5(8):1303-1318. doi: 10.1038/s42255-023-00857-0. Epub 2023 Aug 14. Nat Metab. 2023. PMID: 37580540 Free PMC article.
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.
Leach JDG, Vlahov N, Tsantoulis P, Ridgway RA, Flanagan DJ, Gilroy K, Sphyris N, Vázquez EG, Vincent DF, Faller WJ, Hodder MC, Raven A, Fey S, Najumudeen AK, Strathdee D, Nixon C, Hughes M, Clark W, Shaw R; S:CORT consortium; van Hooff SR, Huels DJ, Medema JP, Barry ST, Frame MC, Unciti-Broceta A, Leedham SJ, Inman GJ, Jackstadt R, Thompson BJ, Campbell AD, Tejpar S, Sansom OJ. Leach JDG, et al. Among authors: hughes m. Nat Commun. 2021 Jun 8;12(1):3464. doi: 10.1038/s41467-021-23717-5. Nat Commun. 2021. PMID: 34103493 Free PMC article.
New Guinea has the world's richest island flora.
Cámara-Leret R, Frodin DG, Adema F, Anderson C, Appelhans MS, Argent G, Arias Guerrero S, Ashton P, Baker WJ, Barfod AS, Barrington D, Borosova R, Bramley GLC, Briggs M, Buerki S, Cahen D, Callmander MW, Cheek M, Chen CW, Conn BJ, Coode MJE, Darbyshire I, Dawson S, Dransfield J, Drinkell C, Duyfjes B, Ebihara A, Ezedin Z, Fu LF, Gideon O, Girmansyah D, Govaerts R, Fortune-Hopkins H, Hassemer G, Hay A, Heatubun CD, Hind DJN, Hoch P, Homot P, Hovenkamp P, Hughes M, Jebb M, Jennings L, Jimbo T, Kessler M, Kiew R, Knapp S, Lamei P, Lehnert M, Lewis GP, Linder HP, Lindsay S, Low YW, Lucas E, Mancera JP, Monro AK, Moore A, Middleton DJ, Nagamasu H, Newman MF, Nic Lughadha E, Melo PHA, Ohlsen DJ, Pannell CM, Parris B, Pearce L, Penneys DS, Perrie LR, Petoe P, Poulsen AD, Prance GT, Quakenbush JP, Raes N, Rodda M, Rogers ZS, Schuiteman A, Schwartsburd P, Scotland RW, Simmons MP, Simpson DA, Stevens P, Sundue M, Testo W, Trias-Blasi A, Turner I, Utteridge T, Walsingham L, Webber BL, Wei R, Weiblen GD, Weigend M, Weston P, de Wilde W, Wilkie P, Wilmot-Dear CM, Wilson HP, Wood JRI, Zhang LB, van Welzen PC. Cámara-Leret R, et al. Among authors: hughes m. Nature. 2020 Aug;584(7822):579-583. doi: 10.1038/s41586-020-2549-5. Epub 2020 Aug 5. Nature. 2020. PMID: 32760001
Characterization of prehistoric flint mine products.
Sieveking Gde G, Craddock PT, Hughes MJ, Bush P, Ferguson J. Sieveking Gde G, et al. Among authors: hughes mj. Nature. 1970 Oct 17;228(5268):251-4. doi: 10.1038/228251a0. Nature. 1970. PMID: 16058488